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Solid-phase peptide synthesis using N-alpha-trityl-amino acids

AuthorsEritja Casadellà, Ramón ; Albericio, Fernando; Marcos, Miguel Ángel; García De la Torre, Beatriz
KeywordsAmino acid derivatives
Amino protection
N-trityl-amino acids
Protecting Group
Solid phase peptide synthesis
Issue Date2002
PublisherKluwer Academic Publishers
CitationLetters in Peptide Science
AbstractThe preparation of Nα-trityl-amino acids is described. Several derivatives of trifunctional amino acids carrying acid- and base-labile side-chain protecting groups and the trityl group at the Nα position are prepared for first time. The incorporation of Nαtrityl-amino acids into peptide sequences using solid-phase protocols was achieved. The use of the trityl group for the protection of the α-amino group in conjunction with base-labile side-chain protecting groups constitutes a new method for the assembly of peptides in mild conditions.
Publisher version (URL)doi: 10.1023/A:1016247817737
Appears in Collections:(IQAC) Artículos
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