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Cocoa and cocoa flavanol epicatechin improve hepatic lipid metabolism in in vivo and in vitro models. Role of PKCζ

AutorCordero Herrera, Isabel ; Martín, M. Ángeles ; Fernández-Millán, Elisa; Álvarez, Carmen; Goya, Luis ; Ramos, Sonia
Fecha de publicación2015
EditorElsevier
CitaciónJournal of Functional Foods 17: 761- 773 (2015)
Resumen© 2015 Elsevier Ltd. Diabetes alters lipid metabolism that could lead to hepatic steatosis. The present study aimed to investigate the effect of a cocoa-enriched diet in type 2 diabetic Zucker diabetic fatty (ZDF) rats and that of cocoa-flavanol epicatechin (EC) in high-glucose-exposed HepG2 cells on hepatic lipid metabolism. Male ZDF cocoa-fed-rats had decreased body weight gain and improved circulating and hepatic lipid levels. Similarly, EC alleviated the altered lipid values induced in high-glucose-challenged HepG2 cells. The lipid-lowering effect was related to diminished fatty acid synthesis (sterol-regulatory-element-binding protein-1-c and fatty-acid synthase down-regulation), and increased fatty-acid oxidation (proliferator-activated-receptor α up-regulation). These effects depended on 5'-AMP-activated-protein-kinase (AMPK), protein kinase B (AKT) and protein kinase C (PKC)-ζ, which phosphorylated levels returned to control values upon cocoa or EC administration. Moreover, PKCζ played a role on AKT and AMPK regulation. These findings suggest that cocoa and EC protect hepatocytes in vivo and in vitro by improving lipid metabolism through multiple-signalling pathways.
URIhttp://hdl.handle.net/10261/122920
DOI10.1016/j.jff.2015.06.033
Identificadoresdoi: 10.1016/j.jff.2015.06.033
issn: 1756-4646
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