English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/122801
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Influence of the nanostructure of F-doped TiO<inf>2</inf> films on osteoblast growth and function

AuthorsLozano, D.; Hernández-López, J. M.; Esbrit, P.; Arenas, M. A.; Gómez-Barrena, E.; Damborenea, Juan de ; Esteban, Jaime; Pérez-Jorge, C.; Pérez-Tanoira, R.; Conde, A.
Issue Date2015
CitationJournal of Biomedical Materials Research - Part A 103(6): 1985-1990 (2015)
Abstract© 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1985-1990, 2015. © 2014 Wiley Periodicals, Inc. The aim of this study was to evaluate the proliferation and mineralization ability of mouse osteoblastic MC3T3-E1 cells on F-containing TiO<inf>2</inf> films with different morphology and nanostructure that previously confirmed antibacterial properties. F-containing TiO<inf>2</inf> films were fabricated by anodizing Ti-6Al-4V alloy ELI -grade 23. By using a mixture of H<inf>2</inf>SO4/HF acid at 20 V for 5 and 60 min, a TiO<inf>2</inf> film grows with nanoporous (NP) and nanotubular (NT) features, characterized with a pore diameter of 20 and 100 nm, respectively. Fluoride-TiO<inf>2</inf> barrier films (FBL) were produced in 1M NH<inf>4</inf>H<inf>2</inf>PO<inf>4</inf>/0.15M NH<inf>4</inf>F solution at constant voltage controlled at 20 V for 120 min. The amount of F incorporated in the nanostructured oxide films was 6 at % and of 4 at %, for the NP and NT, respectively, while for the FBL film was 12 at %. MC3T3-E1 cells exhibited different behavior when seeded and grown onto these surfaces. Thus, F-doped TiO<inf>2</inf> films with NP structures increased proliferation as well as osteogenic gene expression and the mineralization capacity of these osteoblastic cells. These results confirm that anodizing process is suitable to fabricate multifunctional surfaces on Ti-6Al-4V alloy with improved not only antibacterial but also osteogenic properties useful for bone fixation of prosthetic devices
Publisher version (URL)http://dx.doi.org/10.1002/jbm.a.35337
Identifiersdoi: 10.1002/jbm.a.35337
issn: 1552-4965
Appears in Collections:(CENIM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.