Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/122733
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | A suppressor role for soluble endoglin in cancer |
Autor: | Quintanilla, Miguel CSIC ORCID; Castillo, Gaelle del CSIC; Sánchez-Blanco, Esther CSIC; Martín-Villar, Ester CSIC ORCID; Valbuena-Díez, Ana C. CSIC; Langa, Carmen CSIC; Pérez-Gómez, Eduardo CSIC ORCID CVN; Renart, Jaime CSIC ORCID; Bernabéu, Carmelo CSIC ORCID | Palabras clave: | Soluble endoglin TGF-β Met Cancer Preeclampsia |
Fecha de publicación: | 2015 | Editor: | Smart Science and Technology | Citación: | Cancer Cell & Microenvironment 2(2): e706 (2015) | Resumen: | Elevated levels of a circulating form of the transforming growth factor-β (TGF-β) coreceptor endoglin correlate with poor clinical outcome in different types of cancer. Soluble endoglin (Sol-Eng) is primarily produced by cleavage of cell-surface endoglin by the transmembrane metalloprotease MMP14 that releases most of its extracellular domain. Sol-Eng has been found to contribute to different cardiovascular pathologies, including preeclampsia, a severe hypertensive syndrome of pregnancy. While the anti-angiogenic and pro-hypertensive functions of Sol-Eng appear well established, its role in cancer has not been fully investigated. Recently, we reported that Sol-Eng strongly inhibits signaling through the hepatocyte growth factor (HGF) tyrosine kinase receptor Met in mouse skin spindle carcinoma cells. Sol-Eng also blocked basal and HGF-mediated stimulation of carcinoma cell proliferation, migration and invasion. Taken together, the above results and the anti-angiogenic function exerted by Sol-Eng suggest a suppressor role for Sol-Eng in cancer. This conclusion is discussed in the paradoxical context of Sol-Eng as a marker of poor prognosis and as a potential contributor to the decreased risk of preeclamptic mothers to develop breast cancer later in life. | Descripción: | This work is licensed under a Creative Commons Attribution 4.0 International License. | Versión del editor: | http://dx.doi.org/10.14800/ccm.706 | URI: | http://hdl.handle.net/10261/122733 | DOI: | 10.14800/ccm.706 | ISSN: | 2331-0928 |
Aparece en las colecciones: | (IIBM) Artículos (CIB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
706-4140-2-PB.pdf | 139 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
336
checked on 18-abr-2024
Download(s)
390
checked on 18-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons