English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/122729
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

New insights into the role of podoplanin in epithelial–mesenchymal transition

AutorRenart, Jaime ; Carrasco-Ramírez, Patricia ; Fernández-Muñoz, Beatriz ; Martín-Villar, Ester ; Montero, Lucía; Yurrita, María M. ; Quintanilla, Miguel
Palabras claveActin cytoskeleton
Cancer
CD44
Cell motility
Cell signaling
CLEC-2
ERM
Protein–protein interactions
Fecha de publicación2015
EditorElsevier
CitaciónInternational Review of Cell and Molecular Biology 317(Cap.4): 185-239 (2015)
ResumenPodoplanin is a small mucin-like transmembrane protein expressed in several adult tissues and with an important role during embryogenesis. It is needed for the proper development of kidneys and lungs as well as accurate formation of the lymphatic vascular system. In addition, it is involved in the physiology of the immune system. A wide variety of tumors express podoplanin, both in the malignant cells and in the stroma. Although there are exceptions, the presence of podoplanin results in poor prognosis. The main consequence of forced podoplanin expression in established and tumor-derived cell lines is an increase in cell migration and, eventually, the triggering of an epithelial–mesenchymal transition, whereby cells acquire a fibroblastoid phenotype and increased motility. We will examine the current status of the role of podoplanin in the induction of epithelial–mesenchymal transition as well as the different interactions that lead to this program.
Versión del editorhttp://dx.doi.org/10.1016/bs.ircmb.2015.01.009
URIhttp://hdl.handle.net/10261/122729
DOI10.1016/bs.ircmb.2015.01.009
ISBN978-0-12-802280-1
Aparece en las colecciones: (IIBM) Libros y partes de libros
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
ROLE OF PODOPLANIN.pdf1,24 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.