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New insights into the role of podoplanin in epithelial–mesenchymal transition

AutorRenart, Jaime ; Carrasco-Ramírez, Patricia ; Fernández-Muñoz, Beatriz ; Martín-Villar, Ester ; Montero, Lucía; Yurrita, María M. ; Quintanilla, Miguel
Palabras claveActin cytoskeleton
Cell motility
Cell signaling
Protein–protein interactions
Fecha de publicación2015
CitaciónInternational Review of Cell and Molecular Biology 317(Cap.4): 185-239 (2015)
ResumenPodoplanin is a small mucin-like transmembrane protein expressed in several adult tissues and with an important role during embryogenesis. It is needed for the proper development of kidneys and lungs as well as accurate formation of the lymphatic vascular system. In addition, it is involved in the physiology of the immune system. A wide variety of tumors express podoplanin, both in the malignant cells and in the stroma. Although there are exceptions, the presence of podoplanin results in poor prognosis. The main consequence of forced podoplanin expression in established and tumor-derived cell lines is an increase in cell migration and, eventually, the triggering of an epithelial–mesenchymal transition, whereby cells acquire a fibroblastoid phenotype and increased motility. We will examine the current status of the role of podoplanin in the induction of epithelial–mesenchymal transition as well as the different interactions that lead to this program.
Versión del editorhttp://dx.doi.org/10.1016/bs.ircmb.2015.01.009
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