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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/122643

Glyconanosomes: Disk-shaped nanomaterials for the water solubilization and delivery of hydrophobic molecules

AutorAssali, Mohyeddin ; Cid, Juan José; Pernia Leal, Manuel ; Muñoz-Bravo, Miguel; Fernández, I.; Wellinger, Ralf Erik ; Khiar el Wahabi, Noureddine
Palabras claveCarbon nanotubes
Drug delivery
Noncovalent functionalization
Fecha de publicación5-mar-2013
EditorAmerican Chemical Society
CitaciónACS Nano 7(3): 2145-2153 (2013)
ResumenHerein, we describe the first report on a new class of disk-shaped and quite monodisperse water-soluble nanomaterials that we named glyconanosomes (GNS). GNSs were obtained by sliding out the cylindrical structures formed upon self-organization and photopolymerization of glycolipid 1 on single-walled carbon nanotube (SWCNT) sidewalls. GNSs present a sheltered hydrophobic inner cavity formed by the carbonated tails, surrounded by PEG and lactose moieties. The amphiphilic character of GNSs allows the water solubility of insoluble hydrophobic cargos such as a perylene-bisimide derivative, [60]fullerene, or the anti-carcinogenic drug camptothecin (CPT). GNS/C60 inclusion complexes are able to establish specific interactions between peanut agglutinin (PNA) lectin and the lactose moiety surrounding the complexes, while CPT solubilized by GNS shows higher cytotoxicity toward MCF7-type breast cancer cells than CPT alone. Thus, GNS represents an attractive extension of nanoparticle-based drug delivery systems. © 2013 American Chemical Society.
Versión del editorhttp://dx.doi.org/10.1021/nn304986x
Identificadoresdoi: 10.1021/nn304986x
issn: 1936-0851
e-issn: 1936-086X
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