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http://hdl.handle.net/10261/122587
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Sharma, Rahul | es_ES |
dc.contributor.author | Jost, Daniel | es_ES |
dc.contributor.author | Kind, Jop | es_ES |
dc.contributor.author | Gómez-Saldívar, Georgina | es_ES |
dc.contributor.author | Steensel, Bas van | es_ES |
dc.contributor.author | Askjaer, Peter | es_ES |
dc.contributor.author | Vaillant, Cédric | es_ES |
dc.contributor.author | Meister, Peter | es_ES |
dc.date.accessioned | 2015-09-24T11:13:45Z | - |
dc.date.available | 2015-09-24T11:13:45Z | - |
dc.date.issued | 2014-12 | - |
dc.identifier.citation | Genes and Development 28: 2591-2596 (2014) | es_ES |
dc.identifier.issn | 0890-9369 | - |
dc.identifier.uri | http://hdl.handle.net/10261/122587 | - |
dc.description | This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months. After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International). | - |
dc.description.abstract | The adjustment of X-linked gene expression to the X chromosome copy number (dosage compensation [DC]) has been widely studied as a model of chromosome-wide gene regulation. In Caenorhabditis elegans, DC is achieved by twofold down-regulation of gene expression from both Xs in hermaphrodites. We show that in males, the single X chromosome interacts with nuclear pore proteins, while in hermaphrodites, the DC complex (DCC) impairs this interaction and alters X localization. Our results put forward a structural model of DC in which X-specific sequences locate the X chromosome in transcriptionally active domains in males, while the DCC prevents this in hermaphrodites. | es_ES |
dc.description.sponsorship | Our laboratories are supported by the Swiss National Science Foundation (SNF assistant professor grant PP00P3_133744), the Swiss Foundation forMuscle Diseases Research, and the University of Bern (to P.M.); the French Centre National de la Recherche Scientifique and the Ecole Normale Sup erieure de Lyon (to C.V. and D.J.); the Spanish Ministry of Economy and Competitiveness (BFU2010-15478), the European Regional Development Fund (to P.A.); Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)-Aard en Levenswetenschappen (ALW) Veni (to J.K.); and ZonMW (Medische wetenschappen)-TOP (to B.v.S.). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Cold Spring Harbor Laboratory Press | - |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.title | Differential spatial and structural organization of the X chromosome underlies dosage compensation in C. elegans | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1101/gad.248864.114 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1101/gad.248864.114 | es_ES |
dc.identifier.e-issn | 1549-5477 | - |
dc.rights.license | http://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.contributor.funder | Swiss National Science Foundation | - |
dc.contributor.funder | Swiss Foundation for Research on Muscle Diseases | - |
dc.contributor.funder | University of Bern | - |
dc.contributor.funder | Centre National de la Recherche Scientifique (France) | - |
dc.contributor.funder | Ecole Normale Supérieure de Lyon | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Netherlands Organization for Scientific Research | - |
dc.contributor.funder | Netherlands Organisation for Health Research and Development | - |
dc.relation.csic | Sí | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100009068 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004794 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.pmid | 25452271 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
Aparece en las colecciones: | (CABD) Artículos |
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Fichero | Descripción | Tamaño | Formato | |
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Genes Dev.-2014-Sharma-2591-6.pdf | Main article | 1,48 MB | Adobe PDF | Visualizar/Abrir |
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