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dc.contributor.authorGomollón-Bel, Fernandoes_ES
dc.contributor.authorDelso, J. Ignacio-
dc.contributor.authorTejero, Tomás-
dc.contributor.authorMerino, Pedro-
dc.date.accessioned2015-09-24T09:17:38Z-
dc.date.available2015-09-24T09:17:38Z-
dc.date.issued2014-
dc.identifier.citationCurrent Chemical Biology 8(1): 10-16 (2014)-
dc.identifier.issn2212-7968-
dc.identifier.urihttp://hdl.handle.net/10261/122571-
dc.description.abstractGlycosidase inhibitors are important compounds that can interfere with several biosynthetic processes including N-linked glycosylation and the biosynthesis of several glycoproteins. Understanding the biogenesis of naturally occurring glycosidase inhibitors would be a crucial step towards the chemical synthesis of analogues of choice. This review focuses on the current knowledge regarding the biosynthesis of a series of polyhydroxylated saturated nitrogen heterocycles including nojirimycin and swainsonine among others, with a potent biological activity as inhibitors of glycosidases and transglycosidases.es_ES
dc.description.sponsorshipThis study was supported by the Ministerio de Ciencia e Innovacion (MICINN) and FEDER Program (Madrid, Spain, project CTQ2010-19606) and the Gobierno de Aragon (Zaragoza, Spain, Bioorganic Chemistry Group. E-10). F.G.- B. thanks CSIC for a JAE predoctoral grant.-
dc.language.isoenges_ES
dc.publisherBentham Science Publishers-
dc.relation.isversionofPostprintes_ES
dc.rightsopenAccesses_ES
dc.subjectBiosynthesises_ES
dc.subjectGlycosidase Inhibitorses_ES
dc.titleBiosynthetic Pathways to Glycosidase Inhibitorses_ES
dc.typeartículoes_ES
dc.identifier.doi10.2174/221279680801141112094818-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.2174/221279680801141112094818-
dc.identifier.e-issn1872-3136-
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.contributor.funderEuropean Commission-
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.contributor.funderGobierno de Aragón-
dc.relation.csices_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100010067es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairetypeartículo-
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