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Título: | Biosynthetic Pathways to Glycosidase Inhibitors |
Autor: | Gomollón-Bel, Fernando CSIC ORCID; Delso, J. Ignacio CSIC ORCID; Tejero, Tomás CSIC ORCID; Merino, Pedro CSIC ORCID | Palabras clave: | Biosynthesis Glycosidase Inhibitors |
Fecha de publicación: | 2014 | Editor: | Bentham Science Publishers | Citación: | Current Chemical Biology 8(1): 10-16 (2014) | Resumen: | Glycosidase inhibitors are important compounds that can interfere with several biosynthetic processes including N-linked glycosylation and the biosynthesis of several glycoproteins. Understanding the biogenesis of naturally occurring glycosidase inhibitors would be a crucial step towards the chemical synthesis of analogues of choice. This review focuses on the current knowledge regarding the biosynthesis of a series of polyhydroxylated saturated nitrogen heterocycles including nojirimycin and swainsonine among others, with a potent biological activity as inhibitors of glycosidases and transglycosidases. | Versión del editor: | http://dx.doi.org/10.2174/221279680801141112094818 | URI: | http://hdl.handle.net/10261/122571 | DOI: | 10.2174/221279680801141112094818 | ISSN: | 2212-7968 | E-ISSN: | 1872-3136 |
Aparece en las colecciones: | (ISQCH) Artículos |
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Biosynthetic Pathways.pdf | 596,98 kB | Adobe PDF | Visualizar/Abrir |
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