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Título

Biosynthetic Pathways to Glycosidase Inhibitors

AutorGomollón-Bel, Fernando CSIC ORCID; Delso, J. Ignacio CSIC ORCID; Tejero, Tomás CSIC ORCID; Merino, Pedro CSIC ORCID
Palabras claveBiosynthesis
Glycosidase Inhibitors
Fecha de publicación2014
EditorBentham Science Publishers
CitaciónCurrent Chemical Biology 8(1): 10-16 (2014)
ResumenGlycosidase inhibitors are important compounds that can interfere with several biosynthetic processes including N-linked glycosylation and the biosynthesis of several glycoproteins. Understanding the biogenesis of naturally occurring glycosidase inhibitors would be a crucial step towards the chemical synthesis of analogues of choice. This review focuses on the current knowledge regarding the biosynthesis of a series of polyhydroxylated saturated nitrogen heterocycles including nojirimycin and swainsonine among others, with a potent biological activity as inhibitors of glycosidases and transglycosidases.
Versión del editorhttp://dx.doi.org/10.2174/221279680801141112094818
URIhttp://hdl.handle.net/10261/122571
DOI10.2174/221279680801141112094818
ISSN2212-7968
E-ISSN1872-3136
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