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Stem cell based therapy for spinal cord injury

AutorVolarevic, Vladislav; Erceg, Slaven; Bhattacharya, Shom Shanker ; Stojkovic, Petra; Horner, Philip; Stojkovic, Miodrag
Palabras claveStem cells (SCs)
Spinal cord injury (SCI)
Fecha de publicación9-ago-2012
EditorCognizant Communication Corporation
CitaciónCell Transplantation 22(8): 1-4 (2012)
ResumenStem cells (SC) represent a new therapeutic approach for spinal cord injury (SCI) by enabling improved sensory and motor functions in animal models. The main goal of SC based therapy for SCI is replacement of neurons and glial cells that undergo cell death soon after injury. Stem cells are able to promote remyelination via oligodendroglia cell replacement, to produce trophic factors enhancing neurite outgrowth, axonal elongation and fibre density and to activate resident or transplanted progenitor cells across the lesion cavity. While several SC transplantation strategies have shown promising yet partial efficacy, mechanistic proof is generally lacking and is arguably the largest impediment toward faster progress and clinical application. The main challenge ahead is to spurn cooperation between clinicians, researchers and patients in order to define and optimize mechanisms of SC function and to establish the ideal source/s of SC that produce efficient and also safe therapeutic approaches.
Versión del editorhttp://dx.doi.org/10.3727/096368912X657260
Identificadoresissn: 0963-6897
e-issn: 1555-3892
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