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Título

Investigation of glycofullerene dynamics by NMR spectroscopy

AutorEngstrom, O.; Muñoz, Antonio; Illescas, Beatriz M.; Martín, Nazario; Ribeiro-Viana, Renato ; Rojo, Javier ; Widmalm, G.
Fecha de publicación2015
EditorRoyal Society of Chemistry (Great Britain)
CitaciónOrganic and Biomolecular Chemistry 13: 8750- 8755 (2015)
Resumen© The Royal Society of Chemistry 2015. Glycofullerenes, in which carbohydrate molecules are attached via a linker to a [60]fullerene core, facilitate spherical presentation of glyco-based epitopes. We herein investigate the dynamics of two glycofullerenes, having 12 and 36 mannose residues at their periphery, by NMR translational diffusion and quantitative <sup>13</sup>C relaxation studies employing a model-free approach for their interpretation. The sugar residues are shown to be highly flexible entities with S<sup>2</sup> < 0.2 in both compounds. Notably, the larger glycofullerene with longer linkers shows faster internal dynamics and higher flexibility than its smaller counterpart. The dynamics and flexibility as well as the slower translational diffusion of the larger glycofullerene, thereby favoring rebinding to a receptor, may together with its spatial extension explain why it is better than the smaller one at blocking the DC-SIGN receptor and inhibiting the infection by pseudotyped Ebola virus particles.
URIhttp://hdl.handle.net/10261/122379
DOI10.1039/c5ob00929d
Identificadoresdoi: 10.1039/c5ob00929d
issn: 1477-0520
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