English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/122379
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Investigation of glycofullerene dynamics by NMR spectroscopy

AuthorsEngstrom, O.; Muñoz, Antonio; Illescas, Beatriz M.; Martín, Nazario; Ribeiro-Viana, Renato ; Rojo, Javier ; Widmalm, G.
Issue Date2015
PublisherRoyal Society of Chemistry (UK)
CitationOrganic and Biomolecular Chemistry 13: 8750- 8755 (2015)
Abstract© The Royal Society of Chemistry 2015. Glycofullerenes, in which carbohydrate molecules are attached via a linker to a [60]fullerene core, facilitate spherical presentation of glyco-based epitopes. We herein investigate the dynamics of two glycofullerenes, having 12 and 36 mannose residues at their periphery, by NMR translational diffusion and quantitative <sup>13</sup>C relaxation studies employing a model-free approach for their interpretation. The sugar residues are shown to be highly flexible entities with S<sup>2</sup> < 0.2 in both compounds. Notably, the larger glycofullerene with longer linkers shows faster internal dynamics and higher flexibility than its smaller counterpart. The dynamics and flexibility as well as the slower translational diffusion of the larger glycofullerene, thereby favoring rebinding to a receptor, may together with its spatial extension explain why it is better than the smaller one at blocking the DC-SIGN receptor and inhibiting the infection by pseudotyped Ebola virus particles.
URIhttp://hdl.handle.net/10261/122379
DOI10.1039/c5ob00929d
Identifiersdoi: 10.1039/c5ob00929d
issn: 1477-0520
Appears in Collections:(IIQ) Artículos
Files in This Item:
File Description SizeFormat 
c5ob00929d.pdf776,26 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.