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Quest for missing proteins: Update 2015 on chromosome-centric human proteome project

AutorHorvatovich, Péter; Corrales, Fernando J.; Casal, J. Ignacio ; Pascual-Montano, Alberto; Albar, Juan Pablo; Fuentes, Manuel; González González, María; Díez, Paula; Ibarrola, Nieves; Dégano, Rosa M.; Marko-Varga, György; Hancock, William S.
Palabras claveMissing proteins
Chromosome centric human proteome project
Antibody enrichment
Fecha de publicación4-sep-2015
EditorAmerican Chemical Society
CitaciónJournal of Proteome Research 14(9): 3415-3431 (2015)
ResumenThis paper summarizes the recent activities of the Chromosome-Centric Human Proteome Project (C-HPP) consortium, which develops new technologies to identify yet-to-be annotated proteins (termed “missing proteins”) in biological samples that lack sufficient experimental evidence at the protein level for confident protein identification. The C-HPP also aims to identify new protein forms that may be caused by genetic variability, post-translational modifications, and alternative splicing. Proteogenomic data integration forms the basis of the C-HPP’s activities; therefore, we have summarized some of key approaches and their roles in the project. We present new analytical technologies that improve the chemical space and lower detection limits coupled with bioinformatics tools and some publicly available resources that can be used to improve data analysis or support the development of analytical assays. Most of this paper’s contents have been compiled from posters, slides, and discussions presented in the series of C-HPP workshops held during 2014. All data (posters, presentations) used are available at the C-HPP Wiki (http://c-hpp.webhosting.rug.nl/) and in the supporting information.
Descripción49 p.-3 fig.-1 tab.-- Horvatovich, Péter et al.
Versión del editorhttp://dx.doi.org/10.1021/pr5013009
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