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Bis-pyridinium cyclophane derivatives as anti-protozoa drugs

Other TitlesDerivados ciclofánicos de bis-piridinio como fármacos anti-protozoarios
AuthorsGamarro, Francisco; Castanys, Santiago; García-Hernández, Raquel; Manzano, José Ignacio; Campos Rosa, Joaquín M.; Gómez-Pérez, Veronica
Issue Date10-Apr-2014
CitationWO2014053691 A1
Abstract[EN] The invention relates to bis-pyridinium cyclophane derivatives of general formula I, L being a group of formula II, wherein Q is the conjugated base of an organic or inorganic acid and has a negative charge q; A and B are independently selected from a C2-C15 spacer group; R1 y R2 are independently selected from hydrogen, halogen, C1-C10 alkyl, C1-C10 haloalkyl, amino, C1-C10 alkylamino, C1-C10 hydroxyl or alcoxyl; and X1 and X2 are independently selected from NH, NR3, O, S and CH2. The invention also relates to a method for the production of same and to the use thereof as anti-protozoa drugs for the treatment and/or prevention of diseases caused by tripanosomatids, such as leishmaniasis
[ES] La presente invención se refiere a derivados ciclofánicos de bis-piridinio de fórmula general I, siendo L un grupo de fórmula II, donde Q es la base conjugada de un ácido orgánico o inorgánico y tiene carga negativa q; A y B se seleccionan independientemente entre un grupo espaciador C2-C15; R1 y R2 se seleccionan independientemente entre hidrógeno, halógeno, alquilo C1-C10, haloalquilo C1-C10, amino, alquilamino C1-C10, hidroxilo o alcoxilo C1-C10; X1 y X2 se seleccionan independientemente entre NH, NR3, O, S y CH2. Además, la presente invención también protege un método de obtención de los mismos, así como su uso como fármacos anti-protozoarios para el tratamiento y/o prevención de enfermedades producidas por tripanosomátidos, como la leishmaniasis. Formula (I) and (II)
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