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Recent Advances and Future Challenges in Glycan Microarray Technology

AutorPaz, José L. de; Seeberger, Peter H.
Palabras claveMicroarrays
Carbohydrates
Glycomics
Glycobiology
Immobilization chemistry
Fecha de publicación2012
EditorSpringer
CitaciónMethods in Molecular Biology, 808: 1-12 (2012)
ResumenGlycan microarrays, carrying hundreds of different sugars on chip surfaces, have become a standard tool for the study of interactions of biomolecules with carbohydrates. The chip-based format offers important advantages, including the ability to screen in parallel several thousand binding events on a single slide, the minimal amount of sample required for one experiment, and the multivalent display of sugars on the chip that mimics the presentation of carbohydrates in nature. This chapter presents recent advances and future challenges in glycan microarray technology. We describe different immobilization and detection methods as well as applications in glycomics, drug discovery, and biomedicine.
Versión del editorhttp://dx.doi.org/10.1007/978-1-61779-373-8_1
URIhttp://hdl.handle.net/10261/122311
DOI10.1007/978-1-61779-373-8_1
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