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Title

Systems biology approaches to bioremediation

AuthorsLorenzo, Víctor de CSIC ORCID
KeywordsSystems biology
Bioremediation
Issue DateDec-2008
PublisherElsevier
CitationCurrent Opinion in Biotechnology; 19: 6, (2008) 579-589
AbstractBioremediation involves the exposure of a whole mixture of chemical structures to an intricate multispecies metabolic network present in a polluted scenario. The complexity involved in such events is growingly amenable to the conceptual frame and the tools of systems biology. The availability of genes, genomes, and metagenomes of biodegradative micro-organisms make it possible to model and even predict the fate of chemicals through the global metabolic network that results from connecting all known biochemical transactions. Microbial communities thus embody a landscape of pan-enzymes that is shaped by the freely diffusible metabolic pool (epimetabolome). Recent computational resources increasingly help the design of superior biocatalysts for biodegradation and biotransformations of desired chemicals, an objective that capitalizes on the new field of synthetic biology.
Publisher version (URL)http:dx.doi.org/10.1016/j.copbio.2008.10.004
URIhttp://hdl.handle.net/10261/12231
DOI10.1016/j.copbio.2008.10.004
ISSN0958-1669
Appears in Collections:(CNB) Artículos

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