English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/122241
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Nuclear versus cytosolic activity of the yeast Hog1 MAP kinase in response to osmotic and tunicamycin-induced ER stress

AuthorsGarcía Marqués, Sara ; Rández Gil, Francisca ; Prieto Alamán, José Antonio
Issue Date2015
PublisherElsevier
CitationFEBS Letters 589: 2163- 2168 (2015)
Abstract© 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. We examined the physiological significance of the nuclear versus cytosolic localization of the MAPK Hog1p in the ability of yeast cells to cope with osmotic and ER (endoplasmic reticulum) stress. Our results indicate that nuclear import of Hog1p is not critical for osmoadaptation. Plasma membrane-anchored Hog1p is still able to induce increased expression of GPD1 and glycerol accumulation. This is a key osmoregulatory event, although a small production of the osmolyte coupled with the nuclear import of Hog1p is sufficient to provide osmoresistance. On the contrary, the nuclear activity of Hog1p is dispensable for ER stress adaptation.
URIhttp://hdl.handle.net/10261/122241
DOI10.1016/j.febslet.2015.06.021
Identifiersdoi: 10.1016/j.febslet.2015.06.021
issn: 1873-3468
Appears in Collections:(IATA) Artículos
Files in This Item:
File Description SizeFormat 
FEBS Letters-2015-SaraGarcia.pdf371,75 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.