English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/122241
Título

Nuclear versus cytosolic activity of the yeast Hog1 MAP kinase in response to osmotic and tunicamycin-induced ER stress

AutorGarcía Marqués, Sara ; Rández Gil, Francisca ; Prieto Alamán, José Antonio
Fecha de publicación2015
EditorElsevier
CitaciónFEBS Letters 589: 2163- 2168 (2015)
Resumen© 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. We examined the physiological significance of the nuclear versus cytosolic localization of the MAPK Hog1p in the ability of yeast cells to cope with osmotic and ER (endoplasmic reticulum) stress. Our results indicate that nuclear import of Hog1p is not critical for osmoadaptation. Plasma membrane-anchored Hog1p is still able to induce increased expression of GPD1 and glycerol accumulation. This is a key osmoregulatory event, although a small production of the osmolyte coupled with the nuclear import of Hog1p is sufficient to provide osmoresistance. On the contrary, the nuclear activity of Hog1p is dispensable for ER stress adaptation.
URIhttp://hdl.handle.net/10261/122241
DOI10.1016/j.febslet.2015.06.021
Identificadoresdoi: 10.1016/j.febslet.2015.06.021
issn: 1873-3468
Aparece en las colecciones: (IATA) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
FEBS Letters-2015-SaraGarcia.pdf371,75 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.