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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Güimil García, Ramón | es_ES |
dc.contributor.author | Brank, Adam S. | es_ES |
dc.contributor.author | Christman, Judith K. | es_ES |
dc.contributor.author | Márquez, Víctor E. | es_ES |
dc.contributor.author | Eritja Casadellà, Ramón | es_ES |
dc.date.accessioned | 2015-09-16T06:32:42Z | - |
dc.date.available | 2015-09-16T06:32:42Z | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Antisense and Nucleic Acid Drug Development | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/122143 | - |
dc.description.abstract | The incorporation of 5-azacytosine residues into DNA causes potent inhibition of DNA (Cytosine-C5) methyltransferases. The synthesis of oligodeoxyribonucleotides incorporating single or multiple 5-aza-2′-deoxycytidine residues at precise sites was undertaken to generate an array of sequences containing the reactive 5-azacytosine base as specific target sites for enzymatic methylation. Preparation of these modified oligonucleotides requires the use of 2-(p-nitrophenyl)ethyloxycarbonyl (NPEOC) groups for the protection of exocyclic amino functions. These groups are removed under mild conditions, thus avoiding conventional protocols that are detrimental to the integrity of the 5-azacytosine ring. | es_ES |
dc.description.sponsorship | a European Molecular Biology Laboratory, D-69117 Heidelberg, Germany b Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 69198-4525, United States c UNMC/Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 69198-4525, United States d Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, United States e Institut de Biología Molecular de Barcelona, CSIC, Jordi Girona 18-26, E-08034 Barcelona, Spain | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Mary Ann Liebert | es_ES |
dc.relation.isversionof | Preprint | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Cytosine derivative | es_ES |
dc.subject | DNA | es_ES |
dc.subject | oligonucleotide | es_ES |
dc.subject | methyltransferase inhibitor | es_ES |
dc.title | Synthesis of oligonucleotide inhibitors of DNA (Cytosine-C5) methyltransferase containing 5-azacytosine residues at specific sites | es_ES |
dc.type | artículo | es_ES |
dc.description.peerreviewed | No | es_ES |
dc.relation.publisherversion | doi:10.1089/108729001753411335 | es_ES |
dc.identifier.e-issn | 10872906 | - |
dc.relation.csic | Sí | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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antisense2001.pdf | 162,4 kB | Adobe PDF | Visualizar/Abrir |
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