Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/121873
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | A nuclear budding mechanism in transiently arrested cells generates drug-sensitive and drug-resistant cells |
Autor: | Mansilla, Sylvia CSIC ORCID; Bataller, Marc CSIC; Portugal, José CSIC ORCID | Fecha de publicación: | 5-abr-2009 | Editor: | Elsevier | Citación: | Biochemical Pharmacology 78(2): 123-132 (2009) | Resumen: | HCT116 (p53+/+) human colon carcinoma cells treated with nanomolar concentrations of doxorubicin underwent transient senescence, synthesized DNA, showed endopolyploidization, increased their size and became multinucleated without a significant increase in mitosis. Nuclei underwent a budding process that involved the release of buds outside the nuclear membrane, and some of the buds seemed to escape from the polyploid cells. A clonogenic assay showed that some cells proliferated following the initial treatment. In general, cells ensuing after budding were not resistant to a variety of drugs, although some of them turned out to be resistant, indicating a potential selective advantage. Nuclear budding was accompanied by changes in protein levels in the giant cells, including inhibition of p53 and enhanced expression of p21WAF1 and the meiosis-related Mos. The buds might be a mechanism for the segregation and elimination of redundant DNA, or for generating viable aneuploid cells with a potentially extended life span. © 2009 Elsevier Inc. All rights reserved. | Versión del editor: | http://dx.doi.org/10.1016/j.bcp.2009.03.027 | URI: | http://hdl.handle.net/10261/121873 | DOI: | 10.1016/j.bcp.2009.03.027 | Identificadores: | doi: 10.1016/j.bcp.2009.03.027 issn: 0006-2952 |
Aparece en las colecciones: | (IBMB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
30
checked on 24-abr-2024
WEB OF SCIENCETM
Citations
30
checked on 23-feb-2024
Page view(s)
248
checked on 24-abr-2024
Download(s)
86
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.