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Título

Involvement of chromatin and histone deacetylation in SV40T antigen transcription regulation

AutorValls, Ester; Blanco-García, Noemí; Aquizu, Naiara; Piedra, David; Estarás, Conchi ; Cruz, Xavier de la ; Martínez-Balbás, Marian
Fecha de publicación6-mar-2007
EditorOxford University Press
CitaciónNucleic Acids Research 35(6): 1958-1968 (2007)
ResumenSimian Virus 40 (SV40) large T antigen (T Ag) is a multifunctional viral oncoprotein that regulates viral and cellular transcriptional activity. However, the mechanisms by which such regulation occurs remain unclear. Here we show that T antigen represses CBP-mediated transcriptional activity. This repression is concomitant with histone H3 deacetylation and is TSA sensitive. Moreover, our results demonstrate that T antigen interacts with HDAC1 in vitro in an Rb-independent manner. In addition, the overexpression of HDAC1 cooperates with T antigen to antagonize CBP transactivation function and correlates with chromatin deacetylation of the TK promoter. Finally, decreasing HDAC1 levels with small interfering RNA (siRNA) partially abolishes T antigen-induced repression. These findings highlight the importance of the histone acetylation/ deacetylation balance in the cellular transformation mediated by oncoviral proteins. © 2007 The Author(s).
Versión del editorhttp://dx.doi.org/10.1093/nar/gkl1113
URIhttp://hdl.handle.net/10261/121774
DOI10.1093/nar/gkl1113
Identificadoresdoi: 10.1093/nar/gkl1113
issn: 0305-1048
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