Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/121774
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Involvement of chromatin and histone deacetylation in SV40T antigen transcription regulation |
Autor: | Valls, Ester; Blanco-García, Noemí CSIC; Aquizu, Naiara CSIC; Piedra, David; Estarás, Conchi CSIC ORCID; Cruz, Xavier de la CSIC ORCID; Martínez-Balbás, Marian CSIC ORCID | Fecha de publicación: | 6-mar-2007 | Editor: | Oxford University Press | Citación: | Nucleic Acids Research 35(6): 1958-1968 (2007) | Resumen: | Simian Virus 40 (SV40) large T antigen (T Ag) is a multifunctional viral oncoprotein that regulates viral and cellular transcriptional activity. However, the mechanisms by which such regulation occurs remain unclear. Here we show that T antigen represses CBP-mediated transcriptional activity. This repression is concomitant with histone H3 deacetylation and is TSA sensitive. Moreover, our results demonstrate that T antigen interacts with HDAC1 in vitro in an Rb-independent manner. In addition, the overexpression of HDAC1 cooperates with T antigen to antagonize CBP transactivation function and correlates with chromatin deacetylation of the TK promoter. Finally, decreasing HDAC1 levels with small interfering RNA (siRNA) partially abolishes T antigen-induced repression. These findings highlight the importance of the histone acetylation/ deacetylation balance in the cellular transformation mediated by oncoviral proteins. © 2007 The Author(s). | Versión del editor: | http://dx.doi.org/10.1093/nar/gkl1113 | URI: | http://hdl.handle.net/10261/121774 | DOI: | 10.1093/nar/gkl1113 | Identificadores: | doi: 10.1093/nar/gkl1113 issn: 0305-1048 |
Aparece en las colecciones: | (CID) Artículos (IBMB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Valls-Nucl-Acids-Res-2007-v35-n6-p1958.pdf | 656,4 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
11
checked on 27-mar-2024
SCOPUSTM
Citations
19
checked on 28-mar-2024
WEB OF SCIENCETM
Citations
18
checked on 25-feb-2024
Page view(s)
265
checked on 28-mar-2024
Download(s)
206
checked on 28-mar-2024