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Título: | Nanoporous silica microparticle interaction with toll-like receptor agonists in macrophages |
Autor: | Cejudo-Guillén, Marta CSIC ORCID; Ramiro-Guiérrez, M. Lourdes; Labrador-Garrido, Adahir CSIC ORCID; Díaz Cuenca, Aránzazu CSIC ORCID; Pozo, David CSIC ORCID | Palabras clave: | Nanoporous silica microparticles Macrophage Innate immunity Toll-like receptor |
Fecha de publicación: | 27-jul-2012 | Editor: | Elsevier | Citación: | Acta Biomaterialia 8(12): 4295-4303 (2012) | Resumen: | Nanoporous silica microparticles (NSiO2-MP) are considered to be potential drug delivery systems and scaffolding platforms in tissue engineering. However, few biocompatibility studies regarding NSiO2-MP interaction with the immune system have been reported. Toll-like receptors (TLR) are involved in host defence as well as autoimmune and inflammatory diseases. The results show that NSiO2-MP up to 100 μg ml−1 do not affect macrophage cell viability after 24 h cell culture. Moreover, NSiO2-MP do not compromise the cell viability of TLR-activated Raw 264.7 cells, for either cell surface TLR (TLR1/TLR2/TLR4/TLR6) or endocytic compartment TLR (TLR3/TLR7/TLR9). Furthermore, Raw 264.7 cells do not respond to NSiO2-MP exposure in terms of IL-6 or IL-10 secretion. NSiO2-MP co-treatment in the presence of TLR ligands does not impair or enhance the secretion of the pro-inflammatory cytokine IL-6 or the regulatory cytokine IL-10. Thus, NSiO2-MP do not affect macrophage polarization towards a pro-inflammatory or immunosuppressive status, representing added value in terms of biocompatibility compared with other SiO2-based micro- and nanoparticles. | Versión del editor: | http://dx.doi.org/10.1016/j.actbio.2012.07.026 | URI: | http://hdl.handle.net/10261/121670 | DOI: | 10.1016/j.actbio.2012.07.026 | ISSN: | 1742-7061 |
Aparece en las colecciones: | (ICMS) Artículos (CABIMER) Artículos |
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