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Nanoporous silica microparticle interaction with toll-like receptor agonists in macrophages

AuthorsCejudo-Guillén, Marta ; Ramiro-Guiérrez, M. Lourdes; Labrador-Garrido, Adahir ; Díaz Cuenca, Aránzazu ; Pozo, David
KeywordsNanoporous silica microparticles
Innate immunity
Toll-like receptor
Issue Date27-Jul-2012
CitationActa Biomaterialia 8(12): 4295-4303 (2012)
AbstractNanoporous silica microparticles (NSiO2-MP) are considered to be potential drug delivery systems and scaffolding platforms in tissue engineering. However, few biocompatibility studies regarding NSiO2-MP interaction with the immune system have been reported. Toll-like receptors (TLR) are involved in host defence as well as autoimmune and inflammatory diseases. The results show that NSiO2-MP up to 100 μg ml−1 do not affect macrophage cell viability after 24 h cell culture. Moreover, NSiO2-MP do not compromise the cell viability of TLR-activated Raw 264.7 cells, for either cell surface TLR (TLR1/TLR2/TLR4/TLR6) or endocytic compartment TLR (TLR3/TLR7/TLR9). Furthermore, Raw 264.7 cells do not respond to NSiO2-MP exposure in terms of IL-6 or IL-10 secretion. NSiO2-MP co-treatment in the presence of TLR ligands does not impair or enhance the secretion of the pro-inflammatory cytokine IL-6 or the regulatory cytokine IL-10. Thus, NSiO2-MP do not affect macrophage polarization towards a pro-inflammatory or immunosuppressive status, representing added value in terms of biocompatibility compared with other SiO2-based micro- and nanoparticles.
Publisher version (URL)http://dx.doi.org/10.1016/j.actbio.2012.07.026
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