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dc.contributor.authorCeballos-Chávez, Maríaes_ES
dc.contributor.authorRivero, Sabrinaes_ES
dc.contributor.authorGarcía-Gutiérrez, Pabloes_ES
dc.contributor.authorRodríguez-Paredes, Manueles_ES
dc.contributor.authorGarcía-Domínguez, Marioes_ES
dc.contributor.authorBhattacharya, Shom Shankeres_ES
dc.contributor.authorReyes, José C.es_ES
dc.date.accessioned2015-09-04T09:23:30Z-
dc.date.available2015-09-04T09:23:30Z-
dc.date.issued2012-
dc.identifier.citationProceedings of the National Academy of Sciences of the USA 109(21): 8085-8090 (2012)es_ES
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/10261/121665-
dc.description.abstractThe LSD1–CoREST histone demethylase complex is required to repress neuronal genes in nonneuronal tissues. Here we show that sumoylation of Braf35, one of the subunits of the complex, is required to maintain full repression of neuron-specific genes and for occupancy of the LSD1–CoREST complex at its gene targets. Interestingly, expression of Braf35 was sufficient to prevent neuronal differentiation induced by bHLH neurogenic transcription factors in P19 cells and in neuronal progenitors of the chicken embryo neural tube. Sumoylation of Braf35 is required for this antineurogenic activity. We also show that iBraf, a paralogue of Braf35, forms heterodimers with Braf35. Braf35–iBraf heterodimerization impairs Braf35 interaction with the LSD1–CoREST complex and inhibits Braf35 sumoylation. Consistent with these results, iBraf prevents the antineurogenic activity of Braf35 in vivo. Our data uncover a mechanism of regulation of the LSD1–CoREST complex and provide a molecular explanation for the antagonism between Braf35 and iBraf in neuronal differentiation.es_ES
dc.description.sponsorshipThis work was supported by Grants BFU2008-00238 and CSD2006-00049 from the Spanish Ministerio de Ciencia e Innovacion, Grant P06-CVI-4844 from Junta de Andalucía and Fundación Ramón Areces (to J.C.R.), and Grant P09-CTS-04967 from Junta de Andalucía (to S.B.).es_ES
dc.language.isoenges_ES
dc.publisherNational Academy of Sciences (U.S.)es_ES
dc.rightsclosedAccesses_ES
dc.subjectChromatines_ES
dc.subjectNeurogenesises_ES
dc.subjectKDM1es_ES
dc.subjectHMG20Aes_ES
dc.subjectHMG20Bes_ES
dc.titleControl of neuronal differentiation by sumoylation of BRAF35, a subunit of the LSD1-CoREST histone demethylase complexes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1073/pnas.1121522109-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1073/pnas.1121522109es_ES
dc.identifier.e-issn1091-6490-
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.contributor.funderJunta de Andalucíaes_ES
dc.contributor.funderFundación Ramón Areceses_ES
dc.relation.csices_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100008054es_ES
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