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Title

Transcription and Recombination: When RNA Meets DNA

AuthorsAguilera, Andrés ; Gaillard, Hélène
Issue Date1-Aug-2014
PublisherCold Spring Harbor Laboratory Press
CitationCold Spring Harbor Perspectives in Biology 6: a016543 (2014)
AbstractA particularly relevant phenomenon in cell physiology and proliferation is the fact that spontaneous mitotic recombination is strongly enhanced by transcription. The most accepted view is that transcription increases the occurrence of double-strand breaks and/or single-stranded DNA gaps that are repaired by recombination. Most breaks would arise as a consequence of the impact that transcription has on replication fork progression, provoking its stalling and/or breakage. Here, we discuss the mechanisms responsible for the cross talk between transcription and recombination, with emphasis on (1) the transcription–replication conflicts as the main source of recombinogenic DNA breaks, and (2) the formation of cotranscriptional R-loops as a major cause of such breaks. The new emerging questions and perspectives are discussed on the basis of the interference between transcription and replication, as well as the way RNA influences genome dynamics.
Publisher version (URL)http://dx.doi.org/10.1101/cshperspect.a016543
URIhttp://hdl.handle.net/10261/121591
DOI10.1101/cshperspect.a016543
E-ISSN1943-0264
Appears in Collections:(CABIMER) Artículos
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