English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/121582
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Transcription coupled repair at the interface between transcription elongation and mRNP biogenesis

AuthorsGaillard, Hélène ; Aguilera, Andrés
KeywordsNucleotide excision repair
Transcription coupled repair
RNAPII transcription
mRNP biogenesis
CSB/Rad26
THO
Issue DateJan-2013
PublisherElsevier
CitationBiochimica et Biophysica Acta - Gene Regulatory Mechanisms 1829(1): 141-150 (2013)
AbstractDuring transcription, the nascent pre-mRNA associates with mRNA-binding proteins and undergoes a series of processing steps, resulting in export competent mRNA ribonucleoprotein complexes (mRNPs) that are transported into the cytoplasm. Throughout transcription elongation, RNA polymerases frequently deal with a number of obstacles that need to be removed for transcription resumption. One important type of hindrance consists of helix-distorting DNA lesions. Transcription-coupled repair (TC-NER), a specific sub-pathway of nucleotide excision repair, ensures a fast repair of such transcription-blocking lesions. While the nucleotide excision repair reaction is fairly well understood, its regulation and the way it deals with DNA transcription remains largely unknown. In this review, we update our current understanding of the factors involved in TC-NER and discuss their functional interplay with the processes of transcription elongation and mRNP biogenesis. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.
Publisher version (URL)http://dx.doi.org/10.1016/j.bbagrm.2012.09.008
URIhttp://hdl.handle.net/10261/121582
DOI10.1016/j.bbagrm.2012.09.008
ISSN0006-3002
Appears in Collections:(CABIMER) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.