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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/121561
Título

R‐loops cause replication impairment and genome instability during meiosis

AutorCastellano-Pozo, Maikel ; García-Muse, Tatiana ; Aguilera, Andrés
Palabras claveR‐Loops
Saccharomyces Cerevisiae
Caenorhabditis Elegans
Meiotic Replication
Genome Instability
Fecha de publicación10-ago-2012
EditorEuropean Molecular Biology Organization
CitaciónEMBO Reports 13(10): 923-929 (2012)
ResumenR‐loops are harmful structures with a negative impact on transcription and recombination during mitosis, but no information exists for meiosis. We used Saccharomyces cerevisiae and Caenorhabditis elegans THO mutants as a tool to determine the consequences of R‐loops in meiosis. We found that both S. cerevisiae and C. elegans THO mutants show defective meiosis and an impairment of premeiotic replication as well as DNA‐damage accumulation. Importantly, RNase H partially suppressed the replication impairment and the DNA‐damage accumulation. We conclude that R‐loops can form during meiosis causing replication impairment with deleterious results.
Versión del editorhttp://dx.doi.org/10.1038/embor.2012.119
URIhttp://hdl.handle.net/10261/121561
DOI10.1038/embor.2012.119
ISSN1469-221X
E-ISSN1469-3178
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