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Título: | The Caenorhabditis elegans THO Complex Is Required for the Mitotic Cell Cycle and Development |
Autor: | Castellano-Pozo, Maikel CSIC ORCID; García-Muse, Tatiana CSIC ORCID; Aguilera, Andrés CSIC ORCID | Fecha de publicación: | 20-dic-2012 | Editor: | Public Library of Science | Citación: | PLoS ONE 1(12): e52447 (2012) | Resumen: | THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing transcription- and RNA-mediated genome instability in mitosis and meiosis. In mammals THO is essential for embryogenesis, which limits our capacity to analyze the physiological relevance of THO during development and in adult organisms. Using Caenorhabditis elegans as a model system we show that the THO complex is essential for mitotic genome integrity and the developmentally regulated mitotic cell cycles occurring during late postembryonic stages. | Descripción: | This is an open-access article distributed under the terms of the Creative Commons Attribution License. | Versión del editor: | http://dx.doi.org/10.1371/journal.pone.0052447.g004 | URI: | http://hdl.handle.net/10261/121560 | DOI: | 10.1371/journal.pone.0052447 | ISSN: | 1932-6203 | E-ISSN: | 1932-6203 |
Aparece en las colecciones: | (CABIMER) Artículos |
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Caenorhabditis_elegans_THO_complex_CastellanoPozo.pdf | 606,73 kB | Adobe PDF | Visualizar/Abrir |
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