English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/121516
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Insulin resistance and inflammation markers: correlations in obese adolescents.

AutorAguilar Cordero, M. J.; González-Jiménez, E.; Antelo, A.; Perona, J. S.
Fecha de publicaciónjul-2013
CitaciónJournal of Clinical Nursing
ResumenAIMS AND OBJECTIVES: To ascertain whether inflammation markers also correlate with parameters related to insulin resistance and the metabolic syndrome in a group of adolescents. BACKGROUND: Obesity is now considered a chronic low-grade inflammatory process, characterised by alterations in the systemic concentrations of some inflammation markers. Adiponectin, leptin and other inflammatory proteins have been shown to correlate with insulin resistance and the metabolic syndrome in adults. DESIGN: Cross-sectional study in two groups of obese and normal weight adolescents. METHODS: Serum levels of adiponectin, leptin, ceruloplasmin and insulin levels were determined and correlated among them and with anthropometric parameters, blood pressure body mass index and body mass index z-score. RESULTS: Waist circumference, body mass index and blood pressure values correlated significantly with both homoeostasis model assessment for insulin resistance and insulin levels. Ceruloplasmin also correlated with both parameters with a high level of significance. However, leptin levels did not correlate with either homoeostasis model assessment for insulin resistance or insulin, and adiponectin correlated with homoeostasis model assessment for insulin resistance but not insulin. All inflammation markers studied correlated with the body mass index z-score. These correlations were stronger in the group of obese individuals compared to lean ones. CONCLUSIONS: We found a relationship between insulin resistance and some inflammation in adolescents, which was particularly strong in obese individuals and was associated with the development of metabolic syndrome. Among the inflammation markers studied, ceruloplasmin revealed as a potential string marker of insulin resistance in obese adolescents. RELEVANCE TO CLINICAL PRACTICE: The results obtained in this study imply a significant advance in the field of clinical practice of nursing. The adequate understanding by nursing personnel of the inflammatory processes inherent to obesity constitutes a key factor for the prevention of the disease and its complications in adolescents.
DOIdoi: 10.1111/jocn.12034
Aparece en las colecciones: (IG) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Artículo enviado al JCN_2.pdfManuscrito aceptado.1,24 MBAdobe PDFVista previa
Mostrar el registro completo

Este item está licenciado bajo una Licencia Creative Commons Creative Commons