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Title

Liquid separation techniques coupled with mass spectrometry for chiral analysis of pharmaceuticals compounds and their metabolites in biological fluids.

AuthorsErny, Guillaume L.; Cifuentes, Alejandro
KeywordsBiological fluids
LC–MS
CE–MS
Enantiomers
Drugs
Capillary electrophoresis
Hyphenated techniques
Liquid chromatography
Metabolites
Sample preparation
CEC–MS
Issue DateFeb-2006
PublisherElsevier
CitationJournal of Pharmaceutical and Biomedical Analysis, Volume 40, Issue 3, Pages 509-515
AbstractDetermination of the chiral composition of drugs is nowadays a key step in order to determine purity, activity, bioavailability, biodegradation, etc, of pharmaceuticals. In this manuscript, works published for the last 5 years on the analysis of chiral drugs by liquid separation techniques coupled with mass spectrometry are reviewed. Namely, chiral analysis of pharmaceuticals including e.g., antiinflammatories, antihypertensives, relaxants, etc, by liquid chromatography-mass spectrometry and capillary electrophoresis-mass spectrometry are included. The importance and interest of the analysis of the enantiomers of the active compound and its metabolites in different biological fluids (plasma, urine, cerebrospinal fluid, etc) are also discussed.
Publisher version (URL)http://dx.doi.org/10.1016/j.jpba.2005.10.044
URIhttp://hdl.handle.net/10261/12149
DOIdoi:10.1016/j.jpba.2005.10.044
ISSN0731-7085
Appears in Collections:(IFI) Artículos
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