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Título

Liquid separation techniques coupled with mass spectrometry for chiral analysis of pharmaceuticals compounds and their metabolites in biological fluids.

AutorErny, Guillaume L.; Cifuentes, Alejandro
Palabras claveBiological fluids
LC–MS
CE–MS
Enantiomers
Drugs
Capillary electrophoresis
Hyphenated techniques
Liquid chromatography
Metabolites
Sample preparation
CEC–MS
Fecha de publicaciónfeb-2006
EditorElsevier
CitaciónJournal of Pharmaceutical and Biomedical Analysis, Volume 40, Issue 3, Pages 509-515
ResumenDetermination of the chiral composition of drugs is nowadays a key step in order to determine purity, activity, bioavailability, biodegradation, etc, of pharmaceuticals. In this manuscript, works published for the last 5 years on the analysis of chiral drugs by liquid separation techniques coupled with mass spectrometry are reviewed. Namely, chiral analysis of pharmaceuticals including e.g., antiinflammatories, antihypertensives, relaxants, etc, by liquid chromatography-mass spectrometry and capillary electrophoresis-mass spectrometry are included. The importance and interest of the analysis of the enantiomers of the active compound and its metabolites in different biological fluids (plasma, urine, cerebrospinal fluid, etc) are also discussed.
Versión del editorhttp://dx.doi.org/10.1016/j.jpba.2005.10.044
URIhttp://hdl.handle.net/10261/12149
DOIdoi:10.1016/j.jpba.2005.10.044
ISSN0731-7085
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