English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/121004
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


The phase difference between neural drives to antagonist muscles in essential tremor is associated with the relative strength of supraspinal and afferent input

AuthorsGallego, Juan Álvaro CSIC ORCID CVN; Dideriksen, Jakob L.; Holobar, Ales; Ibáñez Pereda, Jaime CSIC ORCID ; Glaser, Vojko; Romero, Juan P.; Benito-León, Julián; Pons Rovira, José Luis CSIC ORCID; Rocón, Eduardo CSIC ORCID; Farina, Dario
Essential tremor
IA afferents
Motor unit
Issue DateJun-2015
PublisherSociety for Neuroscience
CitationJournal of Neuroscience 35(23): 8925-8937 (2015)
AbstractThe pathophysiology of essential tremor (ET), the most common movement disorder, is not fully understood. We investigated which factors determine the variability in the phase difference between neural drives to antagonist muscles, a long-standing observation yet unexplained. We used a computational model to simulate the effects of different levels of voluntary and tremulous synaptic input to antagonistic motoneuron pools on the tremor. We compared these simulations to data from 11 human ET patients. In both analyses, the neural drive to muscle was represented as the pooled spike trains of several motor units, which provides an accurate representation of the common synaptic input to motoneurons. The simulations showed that, for each voluntary input level, the phase difference between neural drives to antagonist muscles is determined by the relative strength of the supraspinal tremor input to the motoneuron pools. In addition, when the supraspinal tremor input to one muscle was weak or absent, Ia afferents provided significant common tremor input due to passive stretch. The simulations predicted that without a voluntary drive (rest tremor) the neural drives would be more likely in phase, while a concurrent voluntary input (postural tremor) would lead more frequently to an out-of-phase pattern. The experimental results matched these predictions, showing a significant change in phase difference between postural and rest tremor. They also indicated that the common tremor input is always shared by the antagonistic motoneuron pools, in agreement with the simulations. Our results highlight that the interplay between supraspinal input and spinal afferents is relevant for tremor generation.
Publisher version (URL)http://dx.doi.org/10.1523/JNEUROSCI.0106-15.2015
Appears in Collections:(CAR) Artículos
(IC) Artículos
Files in This Item:
File Description SizeFormat 
Strength of Supraspinal.pdf2,26 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.