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dc.contributor.authorPorte Visa, Cinta-
dc.contributor.authorJaner, Gemma-
dc.contributor.authorLorusso, L. C.-
dc.contributor.authorOrtiz-Zarragoitia, Maren-
dc.contributor.authorCajaraville, Miren P.-
dc.contributor.authorFossi, Cristina-
dc.contributor.authorCanesi, Laura-
dc.date.accessioned2009-04-02T11:04:45Z-
dc.date.available2009-04-02T11:04:45Z-
dc.date.issued2006-03-22-
dc.identifier.citationComparative Biochemistry and Physiology, Part C: Toxicology an Pharmacology 143(3): 306-315 (2006)en_US
dc.identifier.issn1532-0456-
dc.identifier.urihttp://hdl.handle.net/10261/12068-
dc.description10 pages, 2 tables, 3 figures.-- Printed version published Jul 2006.en_US
dc.description.abstractOrganic pollutants exhibiting endocrine disrupting activity (Endocrine Disruptors—EDs) are prevalent over a wide range in the aquatic ecosystems; most EDs are resistant to environmental degradation and are considered ubiquitous contaminants. The actual potency of EDs is low compared to that of natural hormones, but environmental concentrations may still be sufficiently high to produce detrimental biological effects. Most information on the biological effects and mechanisms of action of EDs has been focused on vertebrates. Here we summarize recent progress in studies on selected aspects of endocrine disruption in marine organisms that are still poorly understood and that certainly deserve further research in the near future. This review, divided in four sections, focuses mainly on invertebrates (effects of EDs and mechanisms of action) and presents data on top predators (large pelagic fish and cetaceans), a group of vertebrates that are particularly at risk due to their position in the food chain. The first section deals with basic pathways of steroid biosynthesis and metabolism as a target for endocrine disruption in invertebrates. In the second section, data on the effects and alternative mechanisms of action of estrogenic compounds in mussel immunocytes are presented, addressing to the importance of investigating full range responses to estrogenic chemicals in ecologically relevant invertebrate species. In the third section we review the potential use of vitellogenin (Vtg)-like proteins as a biomarker of endocrine disruption in marine bivalve molluscs, used worldwide as sentinels in marine biomonitoring programmes. Finally, we summarize the results of a recent survey on ED accumulation and effects on marine fish and mammals, utilizing both classical biomarkers of endocrine disruption in vertebrates and non-lethal techniques, such as non-destructive biomarkers, indicating the toxicological risk for top predator species in the Mediterranean. Overall, the reviewed data underline the potential to identify specific types of responses to specific groups of chemicals such as EDs in order to develop suitable biomarkers that could be useful as diagnostic tools for endocrine disruption in marine invertebrates and vertebrates.en_US
dc.description.sponsorshipWork in the laboratory of L. Canesi was supported by the Italian Ministry of Scientific and Technological Research (fondi Ateneo quota ex 60%). We would like to thank Dr. C. Ciacci and Dr. M. Betti for their invaluable technical assistance. Work in the laboratory of Miren P. Cajaraville was funded by the EU BEEP project (contract no. EVK3-CT2000-00025) and by the University of the Basque Country through a grant to consolidated research groups. Work in the laboratory of C. Fossi was partially financed by grants from the Italian Ministry for the Environment and ICRAM (Istituto Centrale per la Ricerca Scientifica e Tecnologica Associata al Mare). We would like to thank Dr. S. Casini, Dr. L. Marsili, Dr. A. Ausili and Dr. G. Mori for scientific and technical support in the project activities. We would also like to thank Dr. S. Ancora and Dr. T. Romeo, for technical support in the sampling activities in the Large Pelagic Fish Project and all the researchers of the Thetys Research Institute for technical support in the sampling activities in the Marine Mammals Project.en_US
dc.format.extent19968 bytes-
dc.format.mimetypeapplication/msword-
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsclosedAccessen_US
dc.subjectEndocrine disruptorsen_US
dc.subjectMarine invertebratesen_US
dc.subjectTop predatorsen_US
dc.subjectSteroid metabolismen_US
dc.subjectCell signallingen_US
dc.subjectBiomarkersen_US
dc.subjectVitellogeninen_US
dc.subjectCYP1A1en_US
dc.titleEndocrine disruptors in marine organisms: Approaches and perspectivesen_US
dc.typeartículoen_US
dc.identifier.doi10.1016/j.cbpc.2006.03.004-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.cbpc.2006.03.004en_US
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