English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/12020
Título

Side effects of antibiotics on genetic variability

AutorCouce, Alejandro; Blázquez, Jesús
Palabras claveantibiotic resistance
mutation
recombination
horizontal gene transfer
Fecha de publicación2009
EditorJohn Wiley & Sons
ResumenIn recent years, there has been accumulating evidence that antibiotics, besides their antimicrobial action, potentially have a number of undesired side effects that can, at least in some cases, promote genetic variability of bacteria. In addition to resistant variants, antibiotics have also been shown to select mutator clones, thus stimulating evolution towards further resistance. Furthermore, mutations, recombination and horizontal gene transfer have been reported to be somehow affected when bacteria are exposed to subinhibitory concentrations of certain antibiotics. These findings may have implications for the use of antibiotics, because they may have undesired side effects, such as enhancing antibiotic resistance evolution. Here we present data supporting (or not) this fearsome possibility and discuss whether this potential threat should be taken into consideration
URIhttp://hdl.handle.net/10261/12020
DOI10.1111/j.1574-6976.2009.00165.x
Aparece en las colecciones: (CNB) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.