English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/11927
Título

Molecular mechanisms of atherosclerosis in metabolic syndrome: role of reduced IRS2-dependent signaling

AutorGonzález-Navarro, Herminia ; Vinué, Ángela ; Vila-Caballer, Marian; Fortuño, Ana; Beloqui, Oscar; Zalba, Guillermo; Burks, Deborah J.; Díez, Javier; Andrés, Vicente
Palabras claveInsulin resistance/metabolic syndrome
atherosclerosis
IRS2.
AKT
ERK
Fecha de publicación18-sep-2008
EditorAmerican Heart Association
CitaciónArteriosclerosis Thrombosis and Vascular Biology 28 (12): 2187-94 (2008)
ResumenOBJECTIVE: The mechanisms underlying accelerated atherosclerosis in metabolic syndrome (MetS) patients remain poorly defined. In the mouse, complete disruption of insulin receptor substrate-2 (Irs2) causes insulin resistance, MetS-like manifestations, and accelerates atherosclerosis. Here, we performed human, mouse, and cell culture studies to gain insight into the contribution of defective Irs2 signaling to MetS-associated alterations. METHODS AND RESULTS: In circulating leukocytes from insulin-resistant MetS patients, Irs2 and Akt2 mRNA levels inversely correlate with plasma insulin levels and HOMA index and are reduced compared to insulin-sensitive MetS patients. Notably, a moderate reduction in Irs2 expression in fat-fed apolipoprotein E-null mice lacking one allele of Irs2 (apoE(-/-)Irs2(+/-)) accelerates atherosclerosis compared to apoE-null controls, without affecting plaque composition. Partial Irs2 inactivation also increases CD36 and SRA scavenger receptor expression and modified LDL uptake in macrophages, diminishes Akt2 and Ras expression in aorta, and enhances expression of the proatherogenic cytokine MCP1 in aorta and primary vascular smooth muscle cells (VSMCs) and macrophages. Inhibition of AKT or ERK1/2, a downstream target of RAS, upregulates Mcp1 in VSMCs. CONCLUSIONS: Enhanced levels of MCP1 resulting from reduced IRS2 expression and accompanying defects in AKT2 and Ras/ERK1/2 signaling pathways may contribute to accelerated atherosclerosis in MetS states.
Descripción8 pages, PMID: 18802016 [PubMed].-- Artículo presentado a la 2ª Reunión Anual de la Red Temática de Investigación Cooperativa (RECAVA) celebrada en Madrid (España) del 1 al 2 de Noviembre de 2008.
Versión del editorhttp://dx.doi.org/10.1161/ATVBAHA.108.175299
URIhttp://hdl.handle.net/10261/11927
DOI10.1161/ATVBAHA.108.175299
ISSN1079-5642
Aparece en las colecciones: (IBV) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Gonzalez et al_ATVB_2008-aceptado.pdf466,14 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.