English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/11849
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Steroid levels in crinoid echinoderms are altered by exposure to model endocrine disruptors

AuthorsLavado Parra, Ramón; Barbaglio, Alice; Carnevali, M. Daniela Candia; Porte Visa, Cinta
KeywordsEndocrine disruption
Antedon mediterranea
Testosterone
17-Estradiol
Androgenic
Anti-androgenic
Issue Date1-Jun-2006
PublisherElsevier
CitationSteroids 71(6):489-497 (2006)
AbstractSexual steroids (testosterone and estradiol) were measured in the whole body of wild specimens of the crinoid Antedon mediterranea collected from the Tyrrhenian Sea (Italy). Testosterone levels (274–1488 pg/g wet weight (w.w.)) were higher than those of estradiol (60–442 pg/g w.w.) and no significant differences between males and females were observed. No clear seasonal trend was either detected – individuals from February, June and October 2004 analyzed – apart from a peak of estradiol in males in autumn. Nonetheless, dramatic changes on tissue steroid levels were observed when individuals were exposed to model androgenic and anti-androgenic compounds for 2 and 4 weeks. The selected compounds were 17α-methyltestosterone (17α-MT), triphenyltin (TPT), fenarimol (FEN), cyproterone acetate (CPA), and p,p′-DDE. Endogenous testosterone levels were significantly increased after exposure to 17α-MT, TPT and FEN, while different responses were observed for estradiol; 17α-MT and FEN increased endogenous estradiol (up to seven-fold), and TPT lead to a significant decrease. Concerning the anti-androgenic compounds, CPA significantly reduced testosterone in a dose-dependent manner without altering estradiol levels, whereas specimens exposed to p,p′-DDE at a low dose (24 ng/L) for 4 weeks showed a four-fold increase in T levels. Overall, the data show the ability of the selected compounds to alter endogenous steroid concentrations in A. mediterranea, and suggest the existence in this echinoderm species of vertebrate-like mechanisms that can be affected by exposure to androgenic and anti-androgenic chemicals
Description9 pages, 2 figures, 1 table.
Publisher version (URL)http://dx.doi.org/10.1016/j.steroids.2006.01.009
URIhttp://hdl.handle.net/10261/11849
DOI10.1016/j.steroids.2006.01.009
ISSN0039-128x
Appears in Collections:(IDAEA) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.