English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/118343
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Magneto-plasmonic nanoparticles as theranostic platforms for magnetic resonance imaging, drug delivery and NIR hyperthermia applications

AutorMarquina, Clara; Sebastian, Victor; Arruebo, Manuel; Santamaría, Jesús
Fecha de publicación2014
EditorRoyal Society of Chemistry (Great Britain)
CitaciónNanoscale 6(15): 9230-9240 (2014)
ResumenPEGylated magneto-plasmonic nanoparticles with a hollow or semi-hollow interior have been successfully synthesized and their physico-chemical characteristics have been investigated. The hollow interior space can be used to store drugs or other molecules of interest whereas magnetic characterization shows their potential as contrast agents in magnetic resonance imaging (MRI) applications. In addition, their plasmonic characteristics in the near infrared (NIR) region make them efficient in photothermal applications producing high temperature gradients after short irradiation times. We show that by controlling the etching conditions the inner silica shell can be selectively dissolved to achieve a hollow or semi-hollow interior without compromising the magnetic or plasmonic characteristics of the resulting nanoparticles. Magnetic measurements and transmission electron microscopy observations have been used to demonstrate the precise control during the etching process and to select an optimal concentration of the etching reagent and contact time to preserve the inner superparamagnetic iron oxide-based nanoparticles and the plasmonic properties of the constructs. Drug loading capabilities were also evaluated for both semi-hollow and as-synthesized nanoparticles using Rhodamine B isothiocyanate as a model compound. The nanoparticles produced could be potentially used as >theranostic> nanoparticles with both imaging capabilities and a dual therapeutic function (drug delivery and hyperthermia). This journal is © the Partner Organisations 2014.
Descripciónet al.
URIhttp://hdl.handle.net/10261/118343
DOI10.1039/C4NR01588F
Identificadoresdoi: 10.1039/C4NR01588F
issn: 2040-3364
e-issn: 2040-3372
Aparece en las colecciones: (ICMA) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.