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Highly cytotoxic DNA-interacting copper(II) coordination compounds

AutorPaula Silveira-Lacerda, Elisângela de; Roubeau, Olivier; Teat, Simon J.; Gamez, Patrick
Fecha de publicación2014
EditorRoyal Society of Chemistry (Great Britain)
CitaciónMetallomics 6(10): 1853-1868 (2014)
ResumenFour new Schiff-base ligands have been designed and prepared by condensation reaction between hydrazine derivatives (i.e. 2-hydrazinopyridine or 2-hydrazinoquinoline) and mono- or dialdehyde (3-tert-butyl-2-hydroxybenzaldehyde and 5-tert-butyl-2-hydroxyisophthalaldehyde, respectively). Six copper(ii) coordination compounds of various nuclearities have been obtained from these ligands, which are formulated as [Cu(L1)Cl](CH3OH) (1), [Cu(L2)NO3] (2), [Cu2(L3)(ClO4)2(CH3O)(CH3OH)](CH3OH) (3), [Cu2(L4)(ClO4)(OH)(CH3OH)](ClO4) (4), [Cu8(L3)4(NO3)4(OH)5](NO3)3(CH3OH)5(H2O)8 (5) and [Cu3(HL2′)4Cl6](CH3OH)6 (6), as revealed by single-crystal X-ray studies. Their DNA-interacting abilities have been investigated using different characterization techniques, which suggest that the metal complexes act as efficient DNA binders. Moreover, cytotoxicity assays with several cancer cell lines show that some of them are very active, as evidenced by the sub-micromolar IC50 values achieved in some cases.
Descripciónet al.
URIhttp://hdl.handle.net/10261/118293
DOI10.1039/C4MT00152D
Identificadoresdoi: 10.1039/C4MT00152D
issn: 1756-5901
e-issn: 1756-591X
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