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Oxigen and oxidation II: Antioxidant defense system of cellular organisms | Oxígeno y oxidación II: Mecanismos de defensa antioxidante de los sistemas biológicos

AutorJiménez Escrig, Antonio
Fecha de publicación2003
EditorSociedad Española de Dietética y Ciencias de la Alimentación
CitaciónNutricion Clinica y Dietetica Hospitalaria 23: 25- 35 (2003)
ResumenIn the human organism the production of reactive oxygen species and natural antioxidant defense are approximately balanced, but it is easy to tip this balance in favour of the reactive oxygen species and create the situation of oxidative stress. The antioxidant defense system of cellular organisms includes four levels of protection: prevention, interaction, repair, and adaptation. In this review, a description of endogen and dietetic antioxidants is made. In this description if the antioxidant action is produced before or during the exposure of the substrate to oxidative agent, or later when the damage have occurred, is considered. The preventive role of the enzymatic systems superoxide dismutase, catalase, and glutation peroxidase, of the metal quelating proteic systems transferrine, ceruloplasmine and haemoglobine, and of the dietetic antioxidant carotenoids, flavonoids, and vitamin C towards oxidation are analysed. In addition, the interaction role in the oxidative process of hydrosoluble (vitamin C, uric acid, bilirrubine) and liposoluble (vitamin E, ubiquinol, carotenoids, flavonoids) endogen and dietetic antioxidants is described. At least, a brief mention of the repair and adaptation processes in the defense system towards oxidative damage of biological substrates is done.
URIhttp://hdl.handle.net/10261/118216
Identificadoresissn: 0211-6057
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