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Enhanced cytotoxic activity of bile acid cisplatin derivatives by conjugation with gold nanoparticles

AuthorsPérez-Andrés, Martin; Millán, Ángel; Palacio, Fernando; Orfao, Alberto ; Criado, Julio J.; Fuentes, Manuel
KeywordsGold nanoparticles
Cytotoxic activity
Drug delivery
Bile-acid cisplatin derivatives
Issue Date2014
CitationJournal of Inorganic Biochemistry 131: 8-11 (2014)
AbstractThis article explores the potential cytotoxic activity of bile-acid cisplatin derivatives like bisursodeoxycholate(ethylenediamine)platinum(II), PtU2, when conjugated with gold nanoparticles, being a promising alternative to cisplatin in the treatment of cancer due to their lower toxicity. For our purpose we analyzed the intracellular delivery ability of these compounds after conjugation with 20-nm gold nanoparticles (PtU2-AuNPs) in the MG63 (osteosarcoma) cell line. Same platinum uptake after incubation with PtU2 and PtU2-AuNPs-derivatives is associated with a higher cytotoxic activity in case of the platinum-gold nanoparticle conjugate, the overall IC50 of PtU2 being reduced more than 10 fold for these new conjugates. When conjugated with gold nanoparticles, this bile-acid derivative is more efficient than the platinum compound alone in terms of their cytotoxic activity. © 2013 Published by Elsevier Inc.
Descriptionet al.
Identifiersdoi: 10.1016/j.jinorgbio.2013.10.021
issn: 0162-0134
e-issn: 1873-3344
Appears in Collections:(IBMCC) Artículos
(ICMA) Artículos
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