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Título

Enhanced cytotoxic activity of bile acid cisplatin derivatives by conjugation with gold nanoparticles

AutorPérez-Andrés, Martin; Millán, Ángel; Palacio, Fernando; Orfao, Alberto; Criado, Julio J.; Fuentes, Manuel
Palabras claveGold nanoparticles
Cytotoxic activity
Drug delivery
Bile-acid cisplatin derivatives
Fecha de publicación2014
EditorElsevier
CitaciónJournal of Inorganic Biochemistry 131: 8-11 (2014)
ResumenThis article explores the potential cytotoxic activity of bile-acid cisplatin derivatives like bisursodeoxycholate(ethylenediamine)platinum(II), PtU2, when conjugated with gold nanoparticles, being a promising alternative to cisplatin in the treatment of cancer due to their lower toxicity. For our purpose we analyzed the intracellular delivery ability of these compounds after conjugation with 20-nm gold nanoparticles (PtU2-AuNPs) in the MG63 (osteosarcoma) cell line. Same platinum uptake after incubation with PtU2 and PtU2-AuNPs-derivatives is associated with a higher cytotoxic activity in case of the platinum-gold nanoparticle conjugate, the overall IC50 of PtU2 being reduced more than 10 fold for these new conjugates. When conjugated with gold nanoparticles, this bile-acid derivative is more efficient than the platinum compound alone in terms of their cytotoxic activity. © 2013 Published by Elsevier Inc.
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URIhttp://hdl.handle.net/10261/118110
DOI10.1016/j.jinorgbio.2013.10.021
Identificadoresdoi: 10.1016/j.jinorgbio.2013.10.021
issn: 0162-0134
e-issn: 1873-3344
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