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Determination of antimicrobial residues and metabolites in the aquatic environment by liquid chromatography tandem mass spectrometry

AuthorsDíaz-Cruz, M. Silvia ; Barceló, Damià
Solid-phase extraction
Liquid chromatography tandem mass spectrometry
Water analysis
Issue Date1-Oct-2006
CitationAnalytical and Bioanalytical Chemistry 386(4):973-985(2006)
AbstractAntimicrobials are used in large quantities in human and veterinary medicine. Their environmental occurrence is of particular concern due to the potential spread and maintenance of bacterial resistance. After intake by the organisms, the unchanged drug and its metabolized forms are excreted and enter wastewater treatment plants where they are mostly incompletely eliminated, and are therefore eventually released into the aquatic environment. The reliable detection of several antimicrobials in different environmental aqueous compartments is the result of great improvements achieved in analytical chemistry. This article provides an overview of the more outstanding analytical methods based on liquid chromatography tandem mass spectrometry, developed and applied to determine antimicrobial residues and metabolites present in surface, waste, and ground waters.
Description13 pages, 2 figures, 3 tables.
Publisher version (URL)http://dx.doi.org/10.1007/s00216-006-0444-z
Appears in Collections:(IDAEA) Artículos
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