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Title

Amphiphilic dendritic derivatives as nanocarriers for the targeted delivery of antimalarial drugs

AuthorsFuente, Jesús M. de la; Sierra, Teresa; Serrano, José Luis; Fernàndez-Busquets, Xavier
KeywordsMalaria
Dendrimers
Nanomedicine
Polymeric nanoparticles
Antimalarial targeted drug delivery
Plasmodium
Issue Date2014
PublisherElsevier
CitationBiomaterials 35(27): 7940-7950 (2014)
AbstractIt can be foreseen that in a future scenario of malaria eradication, a varied armamentarium will be required, including strategies for the targeted administration of antimalarial compounds. The development of nanovectors capable of encapsulating drugs and of delivering them to Plasmodium-infected cells with high specificity and efficacy and at an affordable cost is of particular interest. With this objective, dendritic derivatives based on 2,2-bis(hydroxymethyl)propionic acid (bis-MPA) and Pluronic® polymers have been herein explored. Four different dendritic derivatives have been tested for their capacity to encapsulate the antimalarial drugs chloroquine (CQ) and primaquine (PQ), their specific targeting to Plasmodium-infected red blood cells (pRBCs), and their antimalarial activity invitro against the human pathogen Plasmodium falciparum and invivo against the rodent malaria species Plasmodium yoelii. The results obtained have allowed the identification of two dendritic derivatives exhibiting specific targeting to pRBCs vs. non-infected RBCs, which reduce the invitro IC50 of CQ and PQ by ca. 3- and 4-fold down to 4.0nm and 1.1μm, respectively. This work on the application of dendritic derivatives to antimalarial targeted drug delivery opens the way for the use of this new type of chemicals in future malaria eradication programs. © 2014 Elsevier Ltd.
Descriptionet al.
URIhttp://hdl.handle.net/10261/118025
DOI10.1016/j.biomaterials.2014.05.061
Identifiersdoi: 10.1016/j.biomaterials.2014.05.061
issn: 0142-9612
e-issn: 1878-5905
Appears in Collections:(ICMA) Artículos
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