English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/11788
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Triphenyltin alters androgen metabolism in the sea urchin Paracentrotus lividus

AutorLavado Parra, Ramón; Sugni, Michela; Carnevali, M. Daniela Candia; Porte Visa, Cinta
Palabras claveParacentrotus lividus
Endocrine disruption
Androgen metabolism
Steroid levels
P450 aromatase
Fecha de publicación18-jul-2006
CitaciónAquatic Toxicology 79(3): 247-256 (2006)
ResumenAndrogen metabolism (androstenedione and testosterone) has been assessed in the digestive tube and gonads of the echinoderm Paracentrotus lividus exposed to different concentrations of the biocide triphenyltin (TPT) in a semi-static water regime for 4 weeks. Key enzymatic activities involved in both synthesis and metabolism of androgens, namely 17β-hydroxysteroid dehydrogenases (17β-HSDs), 3β-HSDs, 5α-reductases, P450-aromatase, palmitoyl-CoA:testosterone acyltransferases (ATAT) and testosterone sulfotransferases (SULT), were investigated in digestive tube and/or gonads of control and TPT-exposed specimens in an attempt to see whether androgen metabolism was altered by exposure. In agreement with previous data for vertebrates, exposure to TPT led to a concentration dependent decrease of P450-aromatase that was statistically significant at the highest TPT concentration tested (225 ng/L). Additionally, increased metabolism of testosterone to form dihydrotestosterone (DHT) and 5α-androstane-3β,17β-diol was observed, suggesting increased 5α-reductase activity in the gonads of TPT-exposed individuals. Interestingly, exposure to TPT induced testosterone conjugating activities in organisms exposed to medium (SULT) and high (ATAT and SULT) TPT concentrations. Despite the changes of androgen metabolizing enzymes, testosterone levels in gonads remained rather stable. In contrast, an increase in testosterone and a concomitant decrease in estradiol were observed in the coelomic fluid of TPT-exposed organisms. Overall, the data indicate the ability of TPT to modulate androgen metabolism and circulating steroid levels in P. lividus and suggest the existence of regulatory mechanisms to maintain stable endogenous levels of testosterone in gonads. This study also contributes to a better knowledge of echinoderm endocrinology.
Descripción10 pages, 5 figures.-- PMID: 16846652 [PubMed].-- Printed version published Sep 12, 2006.
Versión del editorhttp://dx.doi.org/10.1016/j.aquatox.2006.06.012
Aparece en las colecciones: (IDAEA) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo

Artículos relacionados:

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.