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Spatially-resolved EELS analysis of antibody distribution on biofunctionalized magnetic nanoparticles

AuthorsArenal, Raul; Matteis, Laura de; Custardoy, Laura; Mayoral, Alvaro; Tence, Marcel; Grazú, Valeria; Fuente, Jesús M. de la; Marquina, Clara; Ibarra, M. Ricardo
Issue Date2013
PublisherAmerican Chemical Society
CitationACS Nano 7(5): 4006-4013 (2013)
AbstractSpatially resolved electron energy loss spectroscopy (SR-EELS) using scanning transmission electron microscope (STEM) allows the identification and determination of the spatial distribution of the components/elements of immuno-functionalized core-shell superparamagnetic magnetite nanoparticles. Here, we report that SR-EELS measurements allow the direct identification and study of the biological moieties (protein G and anti-HRP antibody) in complex bionanocarriers of relevance for biomedical applications. Our findings show that the biomacromolecules are located on specific areas on the nanoparticles' surface. In addition, efficiency of this functionalization was evaluated by means of biochemical techniques. © 2013 American Chemical Society.
Identifiersdoi: 10.1021/nn306028t
issn: 1936-0851
e-issn: 1936-086X
Appears in Collections:(ICMA) Artículos
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