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Title

Organometallic benzimidazoles: Synthesis, characterization and antimalarial activity

AuthorsKlahn, A. Hugo; Lahoz, Fernando J. CSIC ORCID
KeywordsResistance
Antimalarial
Cyrhetrene
Ferrocene
Benzimidazoles
Plasmodium falciparum
Issue Date2013
PublisherElsevier
CitationInorganic Chemistry Communication 35: 126-129 (2013)
AbstractA series of ferrocenyl and cyrhetrenyl benzimidazoles were synthesized and characterized. The condensation-cyclization reaction of cyrhetrenecarbaldehyde with 1,2-phenylendiamine or 4-nitro-1,2-phenylendiamine produces only the 2-cyrhetrenyl-benzimidazoles [1-Re-(H, NO2)] whereas with the same diamines, ferrocenecarbaldehyde yields two products: 2-ferrocenyl-benzimidazole [1-Fe-(H, NO2)] and N-ferrocenylmethyl-2-ferrocenyl-benzimidazole [2-Fe-(H, NO2)]. The structures of all products were confirmed by 1H, 13C NMR spectra and MS. The molecular structure of 2-Fe-NO2 was determined by single crystal X-ray analysis. The antimalarial evaluation studies against the CQ susceptible-strain (3D7) and the CQ resistant-strain (W2) of Plasmodium falciparum revealed cyrhetrene conjugates to be most potent of the tested compounds. The presence of the nitro group at the 5-position of organometallic-benzimidazoles [1-M (M = Re, Fe)] also increases the antimalarial activity. © 2013 Elsevier B.V.
Descriptionet al.
URIhttp://hdl.handle.net/10261/117727
DOIhttp://dx.doi.org/10.1016/j.inoche.2013.06.019
Identifiersdoi: 10.1016/j.inoche.2013.06.019
issn: 1387-7003
Appears in Collections:(ICMA) Artículos
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