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dc.contributor.authorJarque, Sergio-
dc.contributor.authorBosch, Carme-
dc.contributor.authorRivas Casado, Marta-
dc.contributor.authorGrimalt, Joan O.-
dc.contributor.authorRaldúa, Demetrio-
dc.contributor.authorPiña, Benjamín-
dc.description.abstractHepatic mRNA levels of the dio2 gene (deiodinase 2), implicated in thyroid hormone homeostasis, were analyzed in trout from six remote lakes in the Pyrenees (Spain) and the Tatra Mountains (Slovakia). Highest levels corresponded to fish from the two coldest lakes in Pyrenees, whereas relatively low levels were found in the Tatra lakes. These values correlated with the presence of highly-brominated polybrominated diphenyl ethers (PBDE) congeners in the muscle of the same animals, reflecting the distribution of these compounds across European mountain ranges. In contrast, cyp1a expression levels, diagnostic for the presence of dioxin-like pollutants, mirrored the distribution of semi-volatile organochlorine compounds, indicating the specificity of the two types of biological responses. Exposure to PDBEs is known to increase transcription of dio2 and other thyroid-related genes in laboratory experiments; we propose that our data reflects the same phenomenon in natural populations, driven by anthropogenic pollutants at the environmental concentrations.es_ES
dc.description.sponsorshipa Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Molecular and Cellular Biology, Jordi Girona, 18, 08034 Barcelona, Spain b Masaryk University, Faculty of Science, RECETOX, Kamenice 5/753, Brno CZ62500, Czech Republices_ES
dc.subjectAirborne pollutiones_ES
dc.subjectAryl hydrocarbon Receptores_ES
dc.subjectPersistent organic pollutantses_ES
dc.subjectSalmo truttaes_ES
dc.titleAnalysis of hepatic deiodinase 2 mRNA levels in natural fish lake populations exposed to different levels of putative thyroid disrupterses_ES
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