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Analysis of hepatic deiodinase 2 mRNA levels in natural fish lake populations exposed to different levels of putative thyroid disrupters

AutorJarque, Sergio; Bosch, Carme; Rivas Casado, Marta; Grimalt, Joan O.; Raldúa, Demetrio; Piña, Benjamín
Palabras claveAirborne pollution
Aryl hydrocarbon Receptor
Persistent organic pollutants
qRT-PCR
Salmo trutta
Fecha de publicación8-jul-2015
ResumenHepatic mRNA levels of the dio2 gene (deiodinase 2), implicated in thyroid hormone homeostasis, were analyzed in trout from six remote lakes in the Pyrenees (Spain) and the Tatra Mountains (Slovakia). Highest levels corresponded to fish from the two coldest lakes in Pyrenees, whereas relatively low levels were found in the Tatra lakes. These values correlated with the presence of highly-brominated polybrominated diphenyl ethers (PBDE) congeners in the muscle of the same animals, reflecting the distribution of these compounds across European mountain ranges. In contrast, cyp1a expression levels, diagnostic for the presence of dioxin-like pollutants, mirrored the distribution of semi-volatile organochlorine compounds, indicating the specificity of the two types of biological responses. Exposure to PDBEs is known to increase transcription of dio2 and other thyroid-related genes in laboratory experiments; we propose that our data reflects the same phenomenon in natural populations, driven by anthropogenic pollutants at the environmental concentrations.
Versión del editor10.1016/j.envpol.2014.01.010
URIhttp://hdl.handle.net/10261/117710
DOI10.1016/j.envpol.2014.01.010
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