English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/117586
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Exposure to metals during pregnancy and neuropsychological development at the age of 4 years

AutorForns, Joan; Fort, Marta; Casas, Maribel; Cáceres, Alejandro; Guxens, M.; Gascón, Mireia I.; García-Esteban, R.; Júlvez, Jordi; Grimalt, Joan O.; Sunyer, Jordi
Palabras claveChild development
Environmental exposure
Heavy metals
Nervous system
Neuropsychology
Fecha de publicación6-jul-2015
ResumenBackground: There is insufficient epidemiological evidence for deciding whether prenatal exposure to the current low-levels of metals in developed countries may affect neuropsychological function in early childhood. Objectives: Our goal was to evaluate potential neurotoxic effects of prenatal exposure to seven metals (cobalt, copper, arsenic, cadmium, antimony, thallium and lead), during the 1st and 3rd trimester of pregnancy, on child neuropsychological development at 4 years of age. Materials and methods: This study was based on a population-based birth cohort established in Sabadell (Catalonia, Spain) as part of the INMA [Environment and Childhood] Project. Metals were measured in 485 urine samples collected from mothers during the 1st and 3rd trimester of pregnancy. We assessed the neuropsychological development of 553 4-year-olds with the McCarthy Scales of Childrens' Abilitites (MSCA), together with their ADHD symptomatology, using the ADHD-DSM-IV criteria. A total of 385 children were included in the present study. Results: We found no statistically significant associations between metals and general cognitive scale or executive function of the MSCA. We found negative coefficients for the exposure to cadmium 1st trimester, cadmium 3rd trimester and lead 3rd trimester on the general cognitive score of MSCA, although these results were not significant. We did not find any association between prenatal exposure to metals and ADHD symptomatology at the age of 4 years. Conclusions: Our results do not suggest that prenatal exposure to current low-levels of metals impairs children's cognitive development during preschool years.
Versión del editor10.1016/j.neuro.2013.10.006
URIhttp://hdl.handle.net/10261/117586
DOI10.1016/j.neuro.2013.10.006
Aparece en las colecciones: (IDAEA) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Metalls_Jforns_V1_revised_Mo.docx125,18 kBMicrosoft Word XMLVisualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.