English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/11740
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 213 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Título

Multi-residue analysis of pharmaceuticals in wastewater by ultra-performance liquid chromatography–quadrupole–time-of-flight mass spectrometry

AutorPetrovic, Mira; Gros, Meritxell; Barceló, Damià
Palabras claveQuadrupole–time-of-flight mass spectrometry
Pharmaceuticals
Environmental analysis
Ultra-performance liquid chromatography
Fecha de publicación6-jun-2006
EditorElsevier
CitaciónJournal of Chromatography A 1124(1-2): 68-81 (2006)
ResumenIn this work, a new multi-residue method using ultra-performance liquid chromatography (UPLC) quadrupole-time-of-flight mass spectrometry (Q–TOF–MS) was developed for screening and confirmation of 29 pharmaceutical compounds belonging to different therapeutical classes: analgesics and antiinflammatories, lipid regulating agents cholesterol lowering statin agents, psychiatric drugs, anti ulcer agents, histamine H2 receptor antagonist, antibiotics and beta-blockers. UPLC uses columns packed with 1.7 μm particles and enables elution of sample components in much narrower, more concentrated bands, resulting in better chromatographic resolution and increased peak height. The typical peak width was 5–10 s at base, permitting very good separation of all compounds in 10 min, which represented an approximate three-fold reduction in the analysis time in comparison to conventional high-performance liquid chromatography (HPLC). Unequivocal identification of target pharmaceutical compounds was based on accurate mass measurement of the molecular ions in the TOF mode and by performing collision induced dissociation (CID) in the Q–TOF mode in order to generate accurate mass measurement of the product ions. Using lock mass correction the accurate masses calculated for the product ions deviated from the theoretical masses by 0.2 to 1.3 mDa (root mean square (RMS) value = 0.67) and 0.7–6.4 ppm (RMS = 3.53), respectively. Quantitation was carried out working in the TOF mode using the narrow window extracted ion chromatograms (nwXICs) of each compound (extracted using a 20 mDa window) yielding relative standard deviation (RSD) from 0.5 to 5.3% (run-to-run) and from 2.1 to 9.1% (day-to-day) and instrumental detection limits (IDLs) from 1 to 200 pg. Analysis of wastewater treatment plant (WWTP) samples gave method detection limits (MDLs) ranging from 10 to 500 ng/L. The UPLC–Q–TOF method was successfully applied to analyze pharmaceutical residues in WWTP samples.
Descripción14 pages, 5 figures, 5 tables.-- PMID: 16759662 [PubMed].-- Printed version published Aug 18, 2006.-- Issue title: ExTech 2006 - 8th International Symposium on Advances in Extraction Techniques (York, UK, Feb 6-8, 2006).
Versión del editorhttp://dx.doi.org/10.1016/j.chroma.2006.05.024
URIhttp://hdl.handle.net/10261/11740
DOI10.1016/j.chroma.2006.05.024
ISSN0021-9673
Aparece en las colecciones: (IDAEA) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.