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Determination of pharmaceuticals of various therapeutic classes by solid-phase extraction and liquid chromatography–tandem mass spectrometry analysis in hospital effluent wastewaters

AuthorsGómez, M. José; Petrovic, Mira CSIC ORCID; Fernández Alba, Amadeo R.; Barceló, Damià CSIC ORCID
KeywordsLiquid chromatography–tandem mass spectrometry
Hospital wastewaters
Issue Date20-Mar-2006
CitationJournal of Chromatography A 1114(2): 224-233 (2006)
AbstractA multi-residue analytical method has been developed and validated for determining a selection of 16 pharmaceuticals: the anti-epileptic carbamazepine, seven analgesic/anti-inflammatory drugs (mefenamic acid, indomethacine, ibuprofen, naproxen, diclofenac, ketorolac and acetaminophen), the analgesic opiate codeine, two antidepressants (fluoxetine and paroxetine), β-blockers (atenolol and propranolol), antibiotic (trimethoprim, metronidazole, and erythromycin) and the anti-ulcer ranitidine in hospital effluent wastewaters. The method allows simultaneous extraction of the pharmaceuticals compounds by solid-phase extraction (SPE) using the Waters Oasis HLB at pH 7. The analytes were then identified and quantitatively determined by liquid chromatography–tandem mass spectrometry (LC–MS–MS) using multiple reaction monitoring (MRM). Recoveries of the pharmaceuticals were higher than 75%, with the exception of ranitidine (45%) and the overall variability of the method was below 9%. The instrumental detection limit (IDL) varied between 2 and 31 pg injected, the method detection limit (LOD) was between 7 and 47 ng/L in spiked hospital effluent. The precision of the method, calculated as relative standard deviation (RSD), ranged from 0.3 to 4.9%. A detail study off matrix effect is included in this work, regarding to signal suppression in these effluent wastewaters from a hospital complex samples. The developed analytical method was applied for preliminary data results in effluent wastewaters from a hospital.
Description10 pages, 3 figures, 3 tables.-- PMID: 16546199 [PubMed].-- Printed version published May 12, 2006.-- Issue title: ExTech 2005 - 7th International Symposium on Advances in Extraction Technologies (Campinas, Brazil, Nov 13-15, 2005).
Presented at the 1st International Workshop on Liquid Chromatography–Tandem Mass Spectrometry for Screening and Trace Level Quantitation in Environmental and Food Samples, Barcelona, Spain, 20–21 June 2005.
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