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Title

Long term functionally requirement of BDNF for sound processing revealed by conditional gene deletion

AuthorsKnipper, Marlies; Singer, Wibke; Zuccotti, Annalisa; Schimmang, Thomas ; Rüttiger, Lukas
Issue Date2014
CitationARO 37th MidWinter Meeting (2014)
Abstract[Background]: The precision of sound information transmitted to the brain depends on the transfer characteristics of the inner hair cell (IHC) ribbon synapse and its multiple contacting auditory fibers. Discharge rate and synchronicity of auditory fibers define the amplitude of sound induced brainstem responses. [Methods]: We used two mouse lines with either a cell specific deletion of brain-derived nerve growth factor (BDNF) in the cochlea and parts of the brainstem and midbrain (BDNF Pax2) or with deletion of BDNF within the entire brain (BDNF TrkC). We looked for molecular and functional differences pre and post acoustic trauma.
[Results]: We found that BDNF is essential for maintaining exocytosis in IHC synapses in high frequency cochlear turns as well as for maintaining proper targeting of associated afferent fibers within this region (Zuccotti et al Knipper 2012 J. Neurosci.). Comparison of this BDNF Pax2 mice with the BDNF TrkC mice revealed that IHC response characteristics pre and post acoustic trauma were triggered by BDNF in the cochlea and not by BDNF in the brain. [Conclusion]: Extracellular recording of neurons in the inferior colliculus in BDNF Pax2 mice were performed. A surprising novel role of BDNF dependent steps for sound-processing was unraveled.
DescriptionResumen del trabajo presentado al 37th MidWinter Meeting of the Association for Research in Otorhinolaryngology celebrado en San Diego (US) del 22 al 26 de febrero de 2014.-- et al.
URIhttp://hdl.handle.net/10261/117323
Appears in Collections:(IBGM) Comunicaciones congresos
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