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dc.contributor.authorQuesada, Ernesto-
dc.contributor.authorDelgado, Javier-
dc.contributor.authorGajate, Consuelo-
dc.contributor.authorMollinedo, Faustino-
dc.contributor.authorAcuña, A. Ulises-
dc.contributor.authorAmat-Guerri, Francisco-
dc.date.accessioned2009-03-18T12:44:09Z-
dc.date.available2009-03-18T12:44:09Z-
dc.date.issued2004-09-21-
dc.identifier.citationJournal of medicinal chemistry 47 (22) : 5333-5335 (2004)en_US
dc.identifier.issn0022-2623-
dc.identifier.urihttp://hdl.handle.net/10261/11724-
dc.description.abstractEdelfosine (ET-18-OCH3), a synthetic antitumor ether lipid, is taken up by malignant but not by normal cells, triggering apoptosis in a large variety of human tumor cells. The synthesis of the first fluorescent edelfosine analogue (6), with apoptotic activity comparable to that of the parent drug, is described. Fluorescence microscopy experiments show that 6 selectively labels human cancer cells, accumulating into specific domains of the plasma membrane.en_US
dc.description.sponsorshipThis work was supported by Grants BQU2000-1500, BQU2003-4413, FIS-02/1199, and 1FD97-0622 from the Ministerio de Ciencia y Tecnología, Fondo de Investigación Sanitaria (Spain), and the European Commission. E.Q. and J.D. acknowledge predoctoral grants from the same sources.en_US
dc.format.extent6080 bytes-
dc.format.mimetypeimage/gif-
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsclosedAccessen_US
dc.titleFluorescent Phenylpolyene Analogues of the Ether Phospholipid Edelfosine for the Selective Labeling of Cancer Cellsen_US
dc.typeartículoen_US
dc.identifier.doihttp://dx.doi.org/10.1021/jm049808a-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1021/jm049808aen_US
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