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Lipin-2 reduces proinflammatory lipid signaling induced by saturated fatty acids in macrophages

AutorValdearcos, Martín ; Esquinas, Esperanza ; Meana, Clara ; Peña, Lucía ; Gil-de-Gómez, Luis ; Balsinde, Jesús ; Balboa, María A.
Fecha de publicación2012
Citación4th European Workshop on Lipid Mediators (2012)
ResumenLipin-2 is a member of the lipin family of enzymes, which are key effectors in the biosynthesis of lipids. Mutations in the human lipin- 2 gene are associated with inflammatory-based disorders, however the role of lipin-2 in cells of the immune system remains obscure. In the present work we have investigated the role of lipin-2 in the proinflammatory action of saturated fatty acids in murine and human macrophages. Depletion of lipin-2 promotes the increased expression of the proinflammatory genes Il6, Ccl2 and Tnfα, which depends on the overstimulation of the JNK1/c-Jun pathway by saturated fatty acids. On the contrary, overexpression of lipin-2 reduces the release of proinflamatory factors. Metabolically, the absence of lipin-2 reduces the cellular content of triacylglycerol in saturated fatty acid-overloaded macrophages. Collectively, these studies demonstrate a protective role for lipin-2 in proinflammatory signaling mediated by saturated fatty acids that occurs concomitant with an enhanced cellular capacity for triacylglycerol synthesis. The data provide new insights into the role of lipin-2 in human and murine macrophage biology, and may open new avenues for controlling the fatty acid-related low grade inflammation that constitutes the sine qua non of obesity and associated metabolic disorders.
DescripciónResumen del póster presentado al Fourth European Workshop on Lipid Mediators celebrado en Paris (Francia) del 27 al 28 de septiembre de 2012.
URIhttp://hdl.handle.net/10261/117190
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