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Altered arachidonate distribution in macrophages from caveolin-1 null mice leading to reduced eicosanoid synthesis

AuthorsAstudillo, Alma M. CSIC ORCID; Pérez-Chacón, Gema CSIC ORCID; Meana, Clara CSIC ORCID; Balgoma, David CSIC; Pol, Albert; Pozo, Miguel A. del; Balboa, María A. CSIC ORCID; Balsinde, Jesús CSIC ORCID
Issue Date2012
Citation4th European Workshop on Lipid Mediators (2012)
AbstractIn this work we have studied the effect of caveolin-1 deficiency on the mechanisms that regulate free Arachidonic acid (AA) availability. The results presented here demonstrate that macrophages from caveolin-1- deficient mice exhibit elevated fatty acid incorporation and remodeling and a constitutively increased CoA-independent transacylase activity. Mass spectrometrybased lipidomic analyses reveal stable alterations in the profile of AA distribution among phospholipids, manifested by reduced levels of AA in choline glycerophospholipids but elevated levels in ethanolamine glycerophospholipids and phosphatidylinositol. Furthermore, macrophages from caveolin-1 null mice show decreased AA mobilization and prostaglandin E2 and LTB4 production upon cell stimulation. Collectively, these results provide insight into the role of caveolin-1 in AA homeostasis and suggest an important role for this protein in the eicosanoid biosynthetic response.
DescriptionResumen del póster presentado al Fourth European Workshop on Lipid Mediators celebrado en Paris (Francia) del 27 al 28 de septiembre de 2012.
Appears in Collections:(IBGM) Comunicaciones congresos

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